Making a difference: Monocyte heterogeneity in cardiovascular disease

Ingo Hilgendorf; Filip K. Swirski

doi:10.1007/s11883-012-0274-8

Making a difference: Monocyte heterogeneity in cardiovascular disease

Ingo Hilgendorf
, Filip K. Swirski

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 C^high/low) and humans (CD14^+/dim/- CD16^+/-) in the context of atherosclerosis and its complications.

Original language	English
Pages (from-to)	450-459
Number of pages	10
Journal	Current Atherosclerosis Reports
Volume	14
Issue number	5
DOIs	https://doi.org/10.1007/s11883-012-0274-8
State	Published - Oct 2012
Externally published	Yes

Keywords

Atherosclerosis
CD14
CD16
Cardiovascular disease
Dendritic cells
Extramedullary hematopoeisis
Inflammation
Ly-6C
Macrophage
Monocyte heterogeneity
Monocyte subsets
Myocardial infarction

Access to Document

10.1007/s11883-012-0274-8

Cite this

@article{199bc04150a64e61ab3dd33ebd438c67,

title = "Making a difference: Monocyte heterogeneity in cardiovascular disease",

abstract = "Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 Chigh/low) and humans (CD14+/dim/- CD16+/-) in the context of atherosclerosis and its complications.",

keywords = "Atherosclerosis, CD14, CD16, Cardiovascular disease, Dendritic cells, Extramedullary hematopoeisis, Inflammation, Ly-6C, Macrophage, Monocyte heterogeneity, Monocyte subsets, Myocardial infarction",

author = "Ingo Hilgendorf and Swirski, \{Filip K.\}",

year = "2012",

month = oct,

doi = "10.1007/s11883-012-0274-8",

language = "English",

volume = "14",

pages = "450--459",

journal = "Current Atherosclerosis Reports",

issn = "1523-3804",

publisher = "Springer",

number = "5",

}

TY - JOUR

T1 - Making a difference

T2 - Monocyte heterogeneity in cardiovascular disease

AU - Hilgendorf, Ingo

AU - Swirski, Filip K.

PY - 2012/10

Y1 - 2012/10

N2 - Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 Chigh/low) and humans (CD14+/dim/- CD16+/-) in the context of atherosclerosis and its complications.

AB - Monocytes are frequently described as bone marrow-derived precursors of macrophages. Although many studies support this view, we now appreciate that monocytes neither develop exclusively in the bone marrow nor give rise to all macrophages and dendritic cells. In addition to differentiating to specific leukocyte populations, monocytes, as monocytes, are functionally and ontogenically heterogeneous. In this review we will focus on the development and activity of monocytes and their subsets in mice (Ly-6 Chigh/low) and humans (CD14+/dim/- CD16+/-) in the context of atherosclerosis and its complications.

KW - Atherosclerosis

KW - CD14

KW - CD16

KW - Cardiovascular disease

KW - Dendritic cells

KW - Extramedullary hematopoeisis

KW - Inflammation

KW - Ly-6C

KW - Macrophage

KW - Monocyte heterogeneity

KW - Monocyte subsets

KW - Myocardial infarction

UR - https://www.scopus.com/pages/publications/84870484080

U2 - 10.1007/s11883-012-0274-8

DO - 10.1007/s11883-012-0274-8

M3 - Review article

C2 - 22847772

AN - SCOPUS:84870484080

SN - 1523-3804

VL - 14

SP - 450

EP - 459

JO - Current Atherosclerosis Reports

JF - Current Atherosclerosis Reports

IS - 5

ER -

Making a difference: Monocyte heterogeneity in cardiovascular disease

Abstract

Keywords

Access to Document

Fingerprint

Cite this