TY - JOUR
T1 - Major Publications in the Critical Care Pharmacotherapy Literature
T2 - 2020
AU - Bissell, Brittany D.
AU - Campbell, Jeannee
AU - Collins, Reagan
AU - Cook, Charles
AU - Desai, Dharati
AU - Dewitt, Jessica
AU - Eche, Ifeoma Mary
AU - Eche, Ijeoma Julie
AU - Elsamadisi, Pansy
AU - Juul, Janelle
AU - Kim, Soyoung
AU - Makowski, Courtney T.
AU - Mylvaganam, Ruben J.
AU - Smith, Adam
AU - Stancati, Jennifer
AU - Stonesifer, Katherine
AU - Tawil, Justin
AU - Smith Condeni, Melanie
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/12/9
Y1 - 2021/12/9
N2 - OBJECTIVES: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020. DATA SOURCES: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications. STUDY SELECTION: The group reviewed a total of 119 articles during 2020 according to relevance for practice. DATA EXTRACTION: Articles were selected with consensus and importance to clinical practice from those included in the monthly Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. The group reviewed articles according to Grading of Recommendations, Assessment, Development, and Evaluations criteria. Articles with a 1A grade were selected. DATA SYNTHESIS: Several trials were summarized, including two meta-analyses and five original research trials. Original research trials evaluating vitamin C, hydrocortisone, and thiamine versus hydrocortisone in sepsis, the use of nonsedation strategies, dexmedetomidine in cardiac surgery, remdesivir for severe acute respiratory syndrome coronavirus 2, and thrombectomy in acute ischemic stroke. Two meta-analyses determining the impact of norepinephrine initiation in patients with septic shock and the use of corticosteroids in severe acute respiratory syndrome coronavirus 2 was included. CONCLUSIONS: This clinical review provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2020.
AB - OBJECTIVES: To summarize selected meta-analyses and trials related to critical care pharmacotherapy published in 2020. DATA SOURCES: The Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update group screened 36 journals monthly for impactful publications. STUDY SELECTION: The group reviewed a total of 119 articles during 2020 according to relevance for practice. DATA EXTRACTION: Articles were selected with consensus and importance to clinical practice from those included in the monthly Clinical Pharmacy and Pharmacology Pharmacotherapy Literature Update. The group reviewed articles according to Grading of Recommendations, Assessment, Development, and Evaluations criteria. Articles with a 1A grade were selected. DATA SYNTHESIS: Several trials were summarized, including two meta-analyses and five original research trials. Original research trials evaluating vitamin C, hydrocortisone, and thiamine versus hydrocortisone in sepsis, the use of nonsedation strategies, dexmedetomidine in cardiac surgery, remdesivir for severe acute respiratory syndrome coronavirus 2, and thrombectomy in acute ischemic stroke. Two meta-analyses determining the impact of norepinephrine initiation in patients with septic shock and the use of corticosteroids in severe acute respiratory syndrome coronavirus 2 was included. CONCLUSIONS: This clinical review provides summary and perspectives of clinical practice impact on influential critical care pharmacotherapy publications in 2020.
KW - coronavirus disease 2019
KW - critical care
KW - drug therapy
KW - review
KW - sedation
KW - septic shock
UR - http://www.scopus.com/inward/record.url?scp=85144937940&partnerID=8YFLogxK
U2 - 10.1097/CCE.0000000000000590
DO - 10.1097/CCE.0000000000000590
M3 - Article
AN - SCOPUS:85144937940
SN - 2639-8028
VL - 3
SP - E0590
JO - Critical Care Explorations
JF - Critical Care Explorations
IS - 12
ER -