Major depressive disorder and inflammatory markers in elderly patients with heart failure

Anna Maria Andrei, Renerio Fraguas, Renata M.S. Telles, Tânia C.T.F. Alves, Celia M.C. Strunz, Amit Nussbacher, Jairo Rays, Dan V. Iosifescu, Mauricio Wajngarten

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The authors evaluated levels of inflammatory markers in 34 chronic heart failure (CHF) outpatients age 65 years and over, with (N = 18) and without (N = 16) major depressive disorder (MDD), and healthy-control subjects (N = 13). Patients with CHF had left-ventricular ejection fractions <0.40 and were in the New York Heart Association functional class II or III. The authors used the SCID DSM-IV to diagnosis MDD. High-sensitivity C-reactive protein levels were significantly higher in patients with CHF and MDD as compared with healthy-control subjects. No differences regarding tumor necrosis factor α or interleukin6 were found among the three groups.

Original languageEnglish
Pages (from-to)319-324
Number of pages6
JournalPsychosomatics
Volume48
Issue number4
DOIs
StatePublished - 2007

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