Maintenance of brain monoamine oxidase B inhibition in smokers after overnight cigarette abstinence

J. S. Fowler, G. J. Wang, N. D. Volkow, D. Franceschi, J. Logan, N. Pappas, C. Shea, R. R. Macgregor, V. Garza

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Objective: The authors' goal was to replicate a previous finding that smokers have lower brain monoamine oxidase B (MAOB) levels than comparison nonsmoking subjects and to determine if levels recover after overnight cigarette abstinence. Method: Brain MAO-B levels were measured by means of positron emission tomography in six smokers who were scanned twice: 11.3 hours (baseline) and 10 minutes after smoking one cigarette. Results: Average MAO-B levels in smokers in the present study were similar to those found in the previous study and averaged 39% (SD=17) lower than those found in a comparison group of nonsmokers. Brain MAO-B levels did not differ between baseline levels and 10 minutes after smoking. Conclusions: This study reinforces the need to investigate whether MAO-B inhibition may account for some of the behavioral and epidemiological features of smoking.

Original languageEnglish
Pages (from-to)1864-1866
Number of pages3
JournalAmerican Journal of Psychiatry
Volume157
Issue number11
DOIs
StatePublished - 2000
Externally publishedYes

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