Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T

Gagan Joshi; Joseph Biederman; Janet Wozniak; Rachel L. Goldin; Dave Crowley; Stephannie Furtak; Scott E. Lukas; Atilla Gönenç

doi:10.1007/s00406-012-0369-9

Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T

Gagan Joshi, Joseph Biederman, Janet Wozniak, Rachel L. Goldin, Dave Crowley, Stephannie Furtak, Scott E. Lukas, Atilla Gönenç

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 ± 1.8; age range: 12-17 years) with intact intellectual capacity (mean IQ: 108 ± 14.26; IQ range: 85-127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic disorder versus control subjects (paired t test p = 0.01) and a trend for lower Glu in the right medial temporal lobe, which was not statistically different between the groups (paired t test p = 0.06). These preliminary findings support the glutamatergic dysregulation hypothesis in autism and need to be replicated in a larger sample.

Original language	English
Pages (from-to)	379-384
Number of pages	6
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	263
Issue number	5
DOIs	https://doi.org/10.1007/s00406-012-0369-9
State	Published - Aug 2013
Externally published	Yes

Keywords

Autistic disorder
Glutamate
Magnetic resonance spectroscopy
Youth

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10.1007/s00406-012-0369-9

Cite this

Joshi, G., Biederman, J., Wozniak, J., Goldin, R. L., Crowley, D., Furtak, S., Lukas, S. E., & Gönenç, A. (2013). Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T. European Archives of Psychiatry and Clinical Neuroscience, 263(5), 379-384. https://doi.org/10.1007/s00406-012-0369-9

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title = "Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T",

abstract = "The pilot study aimed at examining the neural glutamatergic activity in autism. Seven adolescent males (mean age: 14 ± 1.8; age range: 12-17 years) with intact intellectual capacity (mean IQ: 108 ± 14.26; IQ range: 85-127) suffering from autistic disorder and an equal number of age- and sex-matched healthy controls underwent a two-dimensional magnetic resonance spectroscopy scan at 4T. Results indicated significantly high glutamate (Glu) levels in the anterior cingulate cortex of autistic disorder versus control subjects (paired t test p = 0.01) and a trend for lower Glu in the right medial temporal lobe, which was not statistically different between the groups (paired t test p = 0.06). These preliminary findings support the glutamatergic dysregulation hypothesis in autism and need to be replicated in a larger sample.",

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author = "Gagan Joshi and Joseph Biederman and Janet Wozniak and Goldin, {Rachel L.} and Dave Crowley and Stephannie Furtak and Lukas, {Scott E.} and Atilla G{\"o}nen{\c c}",

note = "Funding Information: Acknowledgments This work was supported by the Pediatric Psychopharmacology Council Fund and the Norma Fine Pediatric Psychopharmacology Fellowship Fund.",

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Joshi, G, Biederman, J, Wozniak, J, Goldin, RL, Crowley, D, Furtak, S, Lukas, SE & Gönenç, A 2013, 'Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T', European Archives of Psychiatry and Clinical Neuroscience, vol. 263, no. 5, pp. 379-384. https://doi.org/10.1007/s00406-012-0369-9

Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T. / Joshi, Gagan; Biederman, Joseph; Wozniak, Janet et al.
In: European Archives of Psychiatry and Clinical Neuroscience, Vol. 263, No. 5, 08.2013, p. 379-384.

Research output: Contribution to journal › Article › peer-review

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AU - Goldin, Rachel L.

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AU - Furtak, Stephannie

AU - Lukas, Scott E.

AU - Gönenç, Atilla

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Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: A pilot study at 4T

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Keywords

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