Magnetic resonance imaging of the atherosclerotic mouse aorta

Jesús Mateo; Marina Benito; Samuel España; Javier Sanz; Jesús Jiménez-Borreguero; Valentín Fuster; Jesús Ruiz-Cabello

doi:10.1007/978-1-4939-2929-0_29

Magnetic resonance imaging of the atherosclerotic mouse aorta

Jesús Mateo, Marina Benito, Samuel España, Javier Sanz, Jesús Jiménez-Borreguero, Valentín Fuster, Jesús Ruiz-Cabello

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T 1, T 2, and proton density).

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	387-394
Number of pages	8
DOIs	https://doi.org/10.1007/978-1-4939-2929-0_29
State	Published - 2015

Publication series

Name	Methods in Molecular Biology
Volume	1339
ISSN (Print)	1064-3745

Keywords

Aorta
ApoE-KO mice
Atherosclerosis
Magnetic resonance imaging (MRI)
Plaque

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10.1007/978-1-4939-2929-0_29

Cite this

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title = "Magnetic resonance imaging of the atherosclerotic mouse aorta",

abstract = "Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T 1, T 2, and proton density).",

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AU - Mateo, Jesús

AU - Benito, Marina

AU - España, Samuel

AU - Sanz, Javier

AU - Jiménez-Borreguero, Jesús

AU - Fuster, Valentín

AU - Ruiz-Cabello, Jesús

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Y1 - 2015

N2 - Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T 1, T 2, and proton density).

AB - Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T 1, T 2, and proton density).

KW - Aorta

KW - ApoE-KO mice

KW - Atherosclerosis

KW - Magnetic resonance imaging (MRI)

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BT - Methods in Molecular Biology

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Magnetic resonance imaging of the atherosclerotic mouse aorta

Abstract

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