Magnetic resonance imaging of the atherosclerotic mouse aorta

Jesús Mateo, Marina Benito, Samuel España, Javier Sanz, Jesús Jiménez-Borreguero, Valentín Fuster, Jesús Ruiz-Cabello

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

Plaque development has been extensively studied using magnetic resonance imaging (MRI) in animal models of rapidly progressing atherosclerosis, such as apolipoprotein E-knockout (apoE-KO) mice. Preclinical MRI plays a significant role in the study of experimental atherosclerosis. Currently, MRI is capable of detecting luminal narrowing, plaque size, and morphology with high accuracy and reproducibility, providing reliable measurements of plaque burden. Therefore, MRI offers a noninvasive approach to serially monitor the progression of the disease. Compared with other imaging modalities, MRI appears to have the greatest potential for plaque characterization, through the use of multiple contrast weightings (e.g., T 1, T 2, and proton density).

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages387-394
Number of pages8
DOIs
StatePublished - 2015

Publication series

NameMethods in Molecular Biology
Volume1339
ISSN (Print)1064-3745

Keywords

  • Aorta
  • ApoE-KO mice
  • Atherosclerosis
  • Magnetic resonance imaging (MRI)
  • Plaque

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