Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia.

I. M. Germano; H. M. Bartkowski; I. Berry; M. Moseley; M. Brant-Zawadzki; L. H. Pitts

Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia.

I. M. Germano
, H. M. Bartkowski
, I. Berry
, M. Moseley
, M. Brant-Zawadzki
, L. H. Pitts

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We evaluated the sensitivity of magnetic resonance (MR) imaging in documenting effects of nimodipine in experimental focal cerebral ischemia. Twenty-five Sprague Dawley rats underwent unilateral occlusion of the middle cerebral artery and were imaged at different intervals thereafter. Neuropathologic and neurologic data were correlated with MR imaging results. Compared with controls, nimodipine-treated rats showed a significantly smaller infarct size (p less than 0.001), as documented by MR imaging and confirmed by neuropathologic evaluations. A less intense signal on the T2 weighted sequence was found in nimodipine-treated rats in basal ganglia (p less than 0.001) and cortex (p less than 0.05). MR imaging may afford unprecedented diagnostic sensitivity in assessing pharmacologic efficacy in cerebral ischemia.

Original language	English
Pages (from-to)	49-52
Number of pages	4
Journal	Acta radiologica. Supplementum
Volume	369
State	Published - 1986
Externally published	Yes

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title = "Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia.",

abstract = "We evaluated the sensitivity of magnetic resonance (MR) imaging in documenting effects of nimodipine in experimental focal cerebral ischemia. Twenty-five Sprague Dawley rats underwent unilateral occlusion of the middle cerebral artery and were imaged at different intervals thereafter. Neuropathologic and neurologic data were correlated with MR imaging results. Compared with controls, nimodipine-treated rats showed a significantly smaller infarct size (p less than 0.001), as documented by MR imaging and confirmed by neuropathologic evaluations. A less intense signal on the T2 weighted sequence was found in nimodipine-treated rats in basal ganglia (p less than 0.001) and cortex (p less than 0.05). MR imaging may afford unprecedented diagnostic sensitivity in assessing pharmacologic efficacy in cerebral ischemia.",

author = "Germano, \{I. M.\} and Bartkowski, \{H. M.\} and I. Berry and M. Moseley and M. Brant-Zawadzki and Pitts, \{L. H.\}",

year = "1986",

language = "English",

volume = "369",

pages = "49--52",

journal = "Acta radiologica. Supplementum",

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T1 - Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia.

AU - Germano, I. M.

AU - Bartkowski, H. M.

AU - Berry, I.

AU - Moseley, M.

AU - Brant-Zawadzki, M.

AU - Pitts, L. H.

PY - 1986

Y1 - 1986

N2 - We evaluated the sensitivity of magnetic resonance (MR) imaging in documenting effects of nimodipine in experimental focal cerebral ischemia. Twenty-five Sprague Dawley rats underwent unilateral occlusion of the middle cerebral artery and were imaged at different intervals thereafter. Neuropathologic and neurologic data were correlated with MR imaging results. Compared with controls, nimodipine-treated rats showed a significantly smaller infarct size (p less than 0.001), as documented by MR imaging and confirmed by neuropathologic evaluations. A less intense signal on the T2 weighted sequence was found in nimodipine-treated rats in basal ganglia (p less than 0.001) and cortex (p less than 0.05). MR imaging may afford unprecedented diagnostic sensitivity in assessing pharmacologic efficacy in cerebral ischemia.

AB - We evaluated the sensitivity of magnetic resonance (MR) imaging in documenting effects of nimodipine in experimental focal cerebral ischemia. Twenty-five Sprague Dawley rats underwent unilateral occlusion of the middle cerebral artery and were imaged at different intervals thereafter. Neuropathologic and neurologic data were correlated with MR imaging results. Compared with controls, nimodipine-treated rats showed a significantly smaller infarct size (p less than 0.001), as documented by MR imaging and confirmed by neuropathologic evaluations. A less intense signal on the T2 weighted sequence was found in nimodipine-treated rats in basal ganglia (p less than 0.001) and cortex (p less than 0.05). MR imaging may afford unprecedented diagnostic sensitivity in assessing pharmacologic efficacy in cerebral ischemia.

UR - https://www.scopus.com/pages/publications/0022821231

M3 - Article

C2 - 2980536

AN - SCOPUS:0022821231

SN - 0001-6926

VL - 369

SP - 49

EP - 52

JO - Acta radiologica. Supplementum

JF - Acta radiologica. Supplementum

ER -

Magnetic resonance imaging in the evaluation of nimodipine-treated acute experimental focal cerebral ischemia.

Abstract

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