Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

Xiaohui Zhang; Dezhuang Ye; Lihua Yang; Yimei Yue; Deborah Sultan; Christopher Pham Pacia; Hannah Pang; Lisa Detering; Gyu Seong Heo; Hannah Luehmann; Ankur Choksi; Abhishek Sethi; David D. Limbrick; Oren J. Becher; Yuan Chuan Tai; Joshua B. Rubin; Hong Chen; Yongjian Liu

doi:10.1021/acsanm.0c02297

Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

Xiaohui Zhang
, Dezhuang Ye
, Lihua Yang
, Yimei Yue
, Deborah Sultan
, Christopher Pham Pacia
, Hannah Pang
, Lisa Detering
, Gyu Seong Heo
, Hannah Luehmann
, Ankur Choksi
, Abhishek Sethi
, David D. Limbrick
, Oren J. Becher
, Yuan Chuan Tai
, Joshua B. Rubin
, Hong Chen
, Yongjian Liu

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used focused ultrasound (FUS) to transiently open BBTB and delivered radiolabeled nanoclusters (64Cu-CuNCs) to tumors for positron emission tomography (PET) imaging and quantification in a mouse DIPG model. First, we optimized FUS acoustic pressure to open the blood-brain barrier (BBB) for the effective delivery of 64Cu-CuNCs to pons in wild-type mice. Then, the optimized FUS pressure was used to deliver radiolabeled agents in DIPG mouse. Magnetic resonance imaging (MRI)-guided FUS-induced BBTB opening was demonstrated using a low-molecular-weight, short-lived 68Ga-DOTA-ECL1i radiotracer and PET/CT before and after treatment. We then compared the delivery efficiency of 64Cu-CuNCs to DIPG tumor with and without FUS treatment and demonstrated the FUS-enhanced delivery and time-dependent diffusion of 64Cu-CuNCs within the tumor.

Original language	English
Pages (from-to)	11129-11134
Number of pages	6
Journal	ACS Applied Nano Materials
Volume	3
Issue number	11
DOIs	https://doi.org/10.1021/acsanm.0c02297
State	Published - 25 Nov 2020
Externally published	Yes

Keywords

diffuse intrinsic pontine glioma
focused ultrasound
magnetic resonance imaging
nanoclusters
positron emission tomography

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10.1021/acsanm.0c02297

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Zhang, X., Ye, D., Yang, L., Yue, Y., Sultan, D., Pacia, C. P., Pang, H., Detering, L., Heo, G. S., Luehmann, H., Choksi, A., Sethi, A., Limbrick, D. D., Becher, O. J., Tai, Y. C., Rubin, J. B., Chen, H., & Liu, Y. (2020). Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma. ACS Applied Nano Materials, 3(11), 11129-11134. https://doi.org/10.1021/acsanm.0c02297

@article{fed993075f7e4d898b7fec80b73170ab,

title = "Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma",

abstract = "Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used focused ultrasound (FUS) to transiently open BBTB and delivered radiolabeled nanoclusters (64Cu-CuNCs) to tumors for positron emission tomography (PET) imaging and quantification in a mouse DIPG model. First, we optimized FUS acoustic pressure to open the blood-brain barrier (BBB) for the effective delivery of 64Cu-CuNCs to pons in wild-type mice. Then, the optimized FUS pressure was used to deliver radiolabeled agents in DIPG mouse. Magnetic resonance imaging (MRI)-guided FUS-induced BBTB opening was demonstrated using a low-molecular-weight, short-lived 68Ga-DOTA-ECL1i radiotracer and PET/CT before and after treatment. We then compared the delivery efficiency of 64Cu-CuNCs to DIPG tumor with and without FUS treatment and demonstrated the FUS-enhanced delivery and time-dependent diffusion of 64Cu-CuNCs within the tumor.",

keywords = "diffuse intrinsic pontine glioma, focused ultrasound, magnetic resonance imaging, nanoclusters, positron emission tomography",

author = "Xiaohui Zhang and Dezhuang Ye and Lihua Yang and Yimei Yue and Deborah Sultan and Pacia, \{Christopher Pham\} and Hannah Pang and Lisa Detering and Heo, \{Gyu Seong\} and Hannah Luehmann and Ankur Choksi and Abhishek Sethi and Limbrick, \{David D.\} and Becher, \{Oren J.\} and Tai, \{Yuan Chuan\} and Rubin, \{Joshua B.\} and Hong Chen and Yongjian Liu",

note = "Publisher Copyright: {\textcopyright} ",

year = "2020",

month = nov,

day = "25",

doi = "10.1021/acsanm.0c02297",

language = "English",

volume = "3",

pages = "11129--11134",

journal = "ACS Applied Nano Materials",

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Zhang, X, Ye, D, Yang, L, Yue, Y, Sultan, D, Pacia, CP, Pang, H, Detering, L, Heo, GS, Luehmann, H, Choksi, A, Sethi, A, Limbrick, DD, Becher, OJ, Tai, YC, Rubin, JB, Chen, H & Liu, Y 2020, 'Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma', ACS Applied Nano Materials, vol. 3, no. 11, pp. 11129-11134. https://doi.org/10.1021/acsanm.0c02297

TY - JOUR

T1 - Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

AU - Zhang, Xiaohui

AU - Ye, Dezhuang

AU - Yang, Lihua

AU - Yue, Yimei

AU - Sultan, Deborah

AU - Pacia, Christopher Pham

AU - Pang, Hannah

AU - Detering, Lisa

AU - Heo, Gyu Seong

AU - Luehmann, Hannah

AU - Choksi, Ankur

AU - Sethi, Abhishek

AU - Limbrick, David D.

AU - Becher, Oren J.

AU - Tai, Yuan Chuan

AU - Rubin, Joshua B.

AU - Chen, Hong

AU - Liu, Yongjian

PY - 2020/11/25

Y1 - 2020/11/25

N2 - Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used focused ultrasound (FUS) to transiently open BBTB and delivered radiolabeled nanoclusters (64Cu-CuNCs) to tumors for positron emission tomography (PET) imaging and quantification in a mouse DIPG model. First, we optimized FUS acoustic pressure to open the blood-brain barrier (BBB) for the effective delivery of 64Cu-CuNCs to pons in wild-type mice. Then, the optimized FUS pressure was used to deliver radiolabeled agents in DIPG mouse. Magnetic resonance imaging (MRI)-guided FUS-induced BBTB opening was demonstrated using a low-molecular-weight, short-lived 68Ga-DOTA-ECL1i radiotracer and PET/CT before and after treatment. We then compared the delivery efficiency of 64Cu-CuNCs to DIPG tumor with and without FUS treatment and demonstrated the FUS-enhanced delivery and time-dependent diffusion of 64Cu-CuNCs within the tumor.

AB - Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood-brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used focused ultrasound (FUS) to transiently open BBTB and delivered radiolabeled nanoclusters (64Cu-CuNCs) to tumors for positron emission tomography (PET) imaging and quantification in a mouse DIPG model. First, we optimized FUS acoustic pressure to open the blood-brain barrier (BBB) for the effective delivery of 64Cu-CuNCs to pons in wild-type mice. Then, the optimized FUS pressure was used to deliver radiolabeled agents in DIPG mouse. Magnetic resonance imaging (MRI)-guided FUS-induced BBTB opening was demonstrated using a low-molecular-weight, short-lived 68Ga-DOTA-ECL1i radiotracer and PET/CT before and after treatment. We then compared the delivery efficiency of 64Cu-CuNCs to DIPG tumor with and without FUS treatment and demonstrated the FUS-enhanced delivery and time-dependent diffusion of 64Cu-CuNCs within the tumor.

KW - diffuse intrinsic pontine glioma

KW - focused ultrasound

KW - magnetic resonance imaging

KW - nanoclusters

KW - positron emission tomography

UR - https://www.scopus.com/pages/publications/85096027299

U2 - 10.1021/acsanm.0c02297

DO - 10.1021/acsanm.0c02297

M3 - Article

AN - SCOPUS:85096027299

SN - 2574-0970

VL - 3

SP - 11129

EP - 11134

JO - ACS Applied Nano Materials

JF - ACS Applied Nano Materials

IS - 11

ER -

Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

Abstract

Keywords

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