Magnetic Hyperthermia Therapy for High-Grade Glioma: A State-of-the-Art Review

Benjamin Rodriguez, Daniel Rivera, Jack Y. Zhang, Cole Brown, Tirone Young, Tyree Williams, Sakibul Huq, Milena Mattioli, Alexandros Bouras, Constantinos G. Hadjpanayis

Research output: Contribution to journalReview articlepeer-review

Abstract

Magnetic hyperthermia therapy (MHT) is a re-emerging treatment modality for brain tumors where magnetic nanoparticles (MNPs) are locally delivered to the brain and then activated with an external alternating magnetic field (AMF) to generate localized heat at a site of interest. Due to the recent advancements in technology and theory surrounding the intervention, clinical and pre-clinical trials have demonstrated that MHT may enhance the effectiveness of chemotherapy and radiation therapy (RT) for the treatment of brain tumors. The future clinical success of MHT relies heavily on designing MNPs optimized for both heating and imaging, developing reliable methods for the local delivery of MNPs, and designing AMF systems with integrated magnetic particle imaging (MPI) for use in humans. However, despite the progression of technological development, the clinical progress of MHT has been underwhelming. This review aims to summarize the current state-of-the-art of MHT and offers insight into the current barriers and potential solutions for moving MHT forward.

Original languageEnglish
Article number300
JournalPharmaceuticals
Volume17
Issue number3
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • HGG = High Grade Glioma
  • MHT: Magnetic Hyperthermia Therapy
  • MNP = Magnetic Nanoparticle
  • glioma
  • hyperthermia

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