Magnesium sulfate ameliorates maternal and fetal inflammation in a rat model of maternal infection

Hima B. Tam Tam, Oonagh Dowling, Xiangying Xue, Dawnette Lewis, Burton Rochelson, Christine N. Metz

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Objective: Magnesium sulfate is proposed to have neuroprotective effects in the offspring. We examined the effects of maternal magnesium sulfate administration on maternal and fetal inflammatory responses in a rat model of maternal infection. Study Design: Pregnant rats were injected with saline, Gram-negative bacterial endotoxin lipopolysaccharide or lipopolysaccharide with magnesium sulfate (pre- and/or after lipopolysaccharide) to mimic infection. Maternal blood, amniotic fluid, fetal blood, and fetal brains were collected 4 hours after lipopolysaccharide and assayed for tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC. In addition, the effect of magnesium sulfate on cytokine production by an astrocytoma cell line was assessed. Results: Lipopolysaccharide administration induced tumor necrosis factor, interleukin-6, monocyte chemoattractant protein-1, and growth-related oncogene-KC expression in maternal and fetal compartments. Maternal magnesium sulfate treatment significantly attenuated lipopolysaccharide-induced multiple proinflammatory mediator levels in maternal and fetal compartments. Conclusion: Antenatal magnesium sulfate administration significantly ameliorated maternal, fetal, and gestational tissue-associated inflammatory responses in an experimental model of maternal infection.

Original languageEnglish
Pages (from-to)364.e1-364.e8
JournalAmerican Journal of Obstetrics and Gynecology
Volume204
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Keywords

  • GRO-KC
  • MCP-1
  • chemokines
  • cytokines
  • fetal brain damage
  • magnesium sulfate
  • maternal infection
  • neuroprotection
  • preterm labor

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