Macrophages in Organ Transplantation

Farideh Ordikhani, Venu Pothula, Rodrigo Sanchez-Tarjuelo, Stefan Jordan, Jordi Ochando

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Current immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in graft rejection, as these mononuclear phagocytic cells recognize alloantigens and trigger an inflammatory cascade that activate the adaptive immune response. Moreover, recent studies suggest that monocytes acquire a feature of memory recall response that is associated with a potent immune response. This form of memory is called “trained immunity,” and it is retained by mechanisms of epigenetic and metabolic changes in innate immune cells after exposure to particular ligands, which have a direct impact in allograft rejection. In this review article, we highlight the role of monocytes and macrophages in organ transplantation and summarize therapeutic approaches to promote tolerance through manipulation of monocytes and macrophages. These strategies may open new therapeutic opportunities to increase long-term transplant survival rates in the clinic.

Original languageEnglish
Article number582939
JournalFrontiers in Immunology
Volume11
DOIs
StatePublished - 30 Nov 2020

Keywords

  • immune tolerance
  • macrophages
  • nanotherapy
  • organ transplantation
  • trained immunity

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