Macrophages in health and disease

Matthew D. Park, Aymeric Silvin, Florent Ginhoux, Miriam Merad

Research output: Contribution to journalReview articlepeer-review

139 Scopus citations

Abstract

The heterogeneity of tissue macrophages, in health and in disease, has become increasingly transparent over the last decade. But with the plethora of data comes a natural need for organization and the design of a conceptual framework for how we can better understand the origins and functions of different macrophages. We propose that the ontogeny of a macrophage—beyond its fundamental derivation as either embryonically or bone marrow-derived, but rather inclusive of the course of its differentiation, amidst steady-state cues, disease-associated signals, and time—constitutes a critical piece of information about its contribution to homeostasis or the progression of disease.

Original languageEnglish
Pages (from-to)4259-4279
Number of pages21
JournalCell
Volume185
Issue number23
DOIs
StatePublished - 10 Nov 2022

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