Abstract
Genome-wide association studies have indicated that MerTK is a risk factor for liver fibrosis in NASH with an unknown mechanism. Cai et al. discovered that MerTK signaling in liver macrophages, which is enhanced in NASH owing to suppression of its cleavage by ADAM17, promotes TGF-β1 production, HSC activation, and liver fibrosis in NASH.
Original language | English |
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Pages (from-to) | 406-421.e7 |
Journal | Cell Metabolism |
Volume | 31 |
Issue number | 2 |
DOIs | |
State | Published - 4 Feb 2020 |
Externally published | Yes |
Keywords
- ADAM17
- MerTK
- MerTK cleavage
- NASH
- TGFβ;
- hepatic stellate cells
- liver fibrosis
- macrophage
- nonalcoholic steatohepatitis
- retinoic acid