@article{9e9e6830fbb146458c60f2efe53451d9,
title = "Macrophage glycolipid receptors for human migration inhibitory factor (MIF): Differentiated HL-60 cells exhibit MIF responsiveness and express surface glycolipids which both bind MIF and convert nonresponsive cells to responsiveness",
abstract = "The human promyelocytic leukemia line HL-60 when treated with a phorbol diester (TPA) differentiates into cells (HL60-TPA) that respond to human migration inhibitory factor (MIF). Unresponsive HL-60 cells became responsive to MIF when preincubated with a glycolipid-enriched preparation extracted from HL60-TPA cells, human monocytes, human macrophage-like (U937) cell line, or with the purified glycolipid receptor for MIF from guinea pig peritoneal macrophages. Human blood monocytes exhibited an increased response to MIF when preincubated with glycolipids from HL60-TPA and U937 cells but not from HL-60 cells, Finally, glycolipids from HL60-TPA cells but not from HL-60 cells were able to reversibly bind MIF when covalently coupled to agarose. These studies suggest that TPA induces the differentiation of HL-60 cells into MIF-responsive cells through the expression of a glycolipid receptor for MIF.",
author = "Liu, {David Y.} and Yu, {Shing Fong} and Remold, {Heinz G.} and David, {John R.}",
note = "Funding Information: {\textquoteright} This work was supported by United States Public Health Service Grants AI-07685, AM-05577, BRSG RR05669, National Science Foundation Grant PCM-8208262, and a Milton Fund Grant. A preliminary report of this work was presented at the 67th Annual Meeting of the Federation of American Societies for Experimental Biology (Fed. Proc. 42,426, 1983). 2 To whom correspondence should be sent at: The Seeley G. Mudd Building, Fifth Floor, 250 Longwood Ave., Boston, Mass. 02 I 15. 3 Abbreviations used in this paper; MIF, migration inhibitory factor; M199-PS, medium 199 with penicillin and streptomycin; TPA, 12-O-tetradecanoylphorbol 13-acetate; HL60-TPA, HL-60 cells differentiated by TPA. Abbreviations for gangliosides are according to the recommendation of the Nomenclature Committee, International Union of the Pure and Applied Chemistry (Lipids 12, 455, 1977). IV3NeuAcI13NeuAcGgOse+Cer( Go,.): (N-acetylneuraminyl) galactosyl-N-acetylgalactosylaminyl(~-acetylneuraminyl)galactosyIglucosylceramide.",
year = "1985",
month = feb,
doi = "10.1016/0008-8749(85)90225-4",
language = "English",
volume = "90",
pages = "605--613",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "2",
}