M-CSF levels during peripheral blood stem cell harvest and autologous stem cell transplantation

K. Saigo; T. Sugimoto; H. Narita; R. Ryo; T. Matsui; M. Yamamoto; S. Kumagai

M-CSF levels during peripheral blood stem cell harvest and autologous stem cell transplantation

K. Saigo
, T. Sugimoto
, H. Narita
, R. Ryo
, T. Matsui
, M. Yamamoto
, S. Kumagai

Research output: Contribution to journal › Article › peer-review

Abstract

Plasma macrophage colony-stimulating factor(M-CSF) levels were determined during peripheral blood stem cell harvest and autologous stem cell transplantation(PBSCT). Plasma of 10 patients were analyzed by using ELISA system. The average peak values during PBSCT were quite higher than those during harvest(20,092 vs 1,681 pg/ml). Peak values were observed mainly around leukocyte nadir(Phase II) during harvest. On the other hand, they were detected just after pretreatment(Phase I) during PBSCT courses. Moreover, samples showing extremely high M-CSF values(Phase I) were associated with increase in serum LDH levels. These data suggest that plasma M-CSF in Phase I are mainly derived from chemotherapy-induced cellular damage during PBSCT courses, and there might be different mechanisms to raise M-CSF around the nadir of leukocytes. It is necessary to elucidate the biological meanings of M-CSF.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	Rinsho byori. The Japanese journal of clinical pathology
Volume	48
Issue number	1
State	Published - Jan 2000
Externally published	Yes

Cite this

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title = "M-CSF levels during peripheral blood stem cell harvest and autologous stem cell transplantation",

abstract = "Plasma macrophage colony-stimulating factor(M-CSF) levels were determined during peripheral blood stem cell harvest and autologous stem cell transplantation(PBSCT). Plasma of 10 patients were analyzed by using ELISA system. The average peak values during PBSCT were quite higher than those during harvest(20,092 vs 1,681 pg/ml). Peak values were observed mainly around leukocyte nadir(Phase II) during harvest. On the other hand, they were detected just after pretreatment(Phase I) during PBSCT courses. Moreover, samples showing extremely high M-CSF values(Phase I) were associated with increase in serum LDH levels. These data suggest that plasma M-CSF in Phase I are mainly derived from chemotherapy-induced cellular damage during PBSCT courses, and there might be different mechanisms to raise M-CSF around the nadir of leukocytes. It is necessary to elucidate the biological meanings of M-CSF.",

author = "K. Saigo and T. Sugimoto and H. Narita and R. Ryo and T. Matsui and M. Yamamoto and S. Kumagai",

year = "2000",

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TY - JOUR

T1 - M-CSF levels during peripheral blood stem cell harvest and autologous stem cell transplantation

AU - Saigo, K.

AU - Sugimoto, T.

AU - Narita, H.

AU - Ryo, R.

AU - Matsui, T.

AU - Yamamoto, M.

AU - Kumagai, S.

PY - 2000/1

Y1 - 2000/1

N2 - Plasma macrophage colony-stimulating factor(M-CSF) levels were determined during peripheral blood stem cell harvest and autologous stem cell transplantation(PBSCT). Plasma of 10 patients were analyzed by using ELISA system. The average peak values during PBSCT were quite higher than those during harvest(20,092 vs 1,681 pg/ml). Peak values were observed mainly around leukocyte nadir(Phase II) during harvest. On the other hand, they were detected just after pretreatment(Phase I) during PBSCT courses. Moreover, samples showing extremely high M-CSF values(Phase I) were associated with increase in serum LDH levels. These data suggest that plasma M-CSF in Phase I are mainly derived from chemotherapy-induced cellular damage during PBSCT courses, and there might be different mechanisms to raise M-CSF around the nadir of leukocytes. It is necessary to elucidate the biological meanings of M-CSF.

AB - Plasma macrophage colony-stimulating factor(M-CSF) levels were determined during peripheral blood stem cell harvest and autologous stem cell transplantation(PBSCT). Plasma of 10 patients were analyzed by using ELISA system. The average peak values during PBSCT were quite higher than those during harvest(20,092 vs 1,681 pg/ml). Peak values were observed mainly around leukocyte nadir(Phase II) during harvest. On the other hand, they were detected just after pretreatment(Phase I) during PBSCT courses. Moreover, samples showing extremely high M-CSF values(Phase I) were associated with increase in serum LDH levels. These data suggest that plasma M-CSF in Phase I are mainly derived from chemotherapy-induced cellular damage during PBSCT courses, and there might be different mechanisms to raise M-CSF around the nadir of leukocytes. It is necessary to elucidate the biological meanings of M-CSF.

UR - https://www.scopus.com/pages/publications/0033657655

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JF - Rinsho byori. The Japanese journal of clinical pathology

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M-CSF levels during peripheral blood stem cell harvest and autologous stem cell transplantation

Abstract

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