M-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia

John H. Krystal; John P. Seibyl; Lawrence H. Price; Scott W. Woods; George R. Heninger; George K. Aghajanian; Dennis S. Charney

doi:10.1001/archpsyc.1993.01820200034004

M-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia

John H. Krystal, John P. Seibyl, Lawrence H. Price, Scott W. Woods, George R. Heninger, George K. Aghajanian, Dennis S. Charney

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Original language	English
Pages (from-to)	624-635
Number of pages	12
Journal	Archives of General Psychiatry
Volume	50
Issue number	8
DOIs	https://doi.org/10.1001/archpsyc.1993.01820200034004
State	Published - Aug 1993
Externally published	Yes

Access to Document

10.1001/archpsyc.1993.01820200034004

Cite this

Krystal, J. H., Seibyl, J. P., Price, L. H., Woods, S. W., Heninger, G. R., Aghajanian, G. K., & Charney, D. S. (1993). M-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia. Archives of General Psychiatry, 50(8), 624-635. https://doi.org/10.1001/archpsyc.1993.01820200034004

@article{33bf50188b964748ab8f30c3ab9e9dc0,

title = "M-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia",

author = "Krystal, {John H.} and Seibyl, {John P.} and Price, {Lawrence H.} and Woods, {Scott W.} and Heninger, {George R.} and Aghajanian, {George K.} and Charney, {Dennis S.}",

note = "Funding Information: This researchwas supported by funding to the Schizo¬ phrenia Biological Research Center and a Merit Review Grant (D.S.C.) from the Department of Veterans Affairs, Washing¬ ton,DC.AdditionalfundingcamefromresearchgrantMH- 30929fromtheNationalInstituteofMentalHealth,Be¬ thesda, Md. Theauthorswish to acknowledge the critical contribu¬ tionstothisresearchprogrammadebytheclinicalandre¬ searchstaffsoftheNeuropsychiatrieStudiesUnitandtheBi¬ ologicalStudiesUnit,WestHavenVeteransAffairsMedical Center,andtheClinicalNeuroscienceResearchUnit,Con¬ necticutMentalHealthCenter.GlennaFreemanandDor¬ othy Soliwoda assisted with gathering of data for prepa¬the rationoftablesforthisreport.PedroMendiaassistedwith statisticalanalyses. ReprintrequeststoSchizophreniaBiologicalResearchCen¬ ter,DepartmentofPsychiatry,YaleUniversitySchoolofMed¬ icine,AffairsWestHavenVeteransMedicalCenter,WestHa¬ ven,Conn06516(DrKrystal).",

year = "1993",

month = aug,

doi = "10.1001/archpsyc.1993.01820200034004",

language = "English",

volume = "50",

pages = "624--635",

journal = "Archives of General Psychiatry",

issn = "0003-990X",

publisher = "American Medical Association",

number = "8",

}

Krystal, JH, Seibyl, JP, Price, LH, Woods, SW, Heninger, GR, Aghajanian, GK & Charney, DS 1993, 'M-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients: Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia', Archives of General Psychiatry, vol. 50, no. 8, pp. 624-635. https://doi.org/10.1001/archpsyc.1993.01820200034004

TY - JOUR

T1 - M-Chlorophenylpiperazine Effects in Neuroleptic-Free Schizophrenic Patients

T2 - Evidence Implicating Serotonergic Systems in the Positive Symptoms of Schizophrenia

AU - Krystal, John H.

AU - Seibyl, John P.

AU - Price, Lawrence H.

AU - Woods, Scott W.

AU - Heninger, George R.

AU - Aghajanian, George K.

AU - Charney, Dennis S.

N1 - Funding Information: This researchwas supported by funding to the Schizo¬ phrenia Biological Research Center and a Merit Review Grant (D.S.C.) from the Department of Veterans Affairs, Washing¬ ton,DC.AdditionalfundingcamefromresearchgrantMH- 30929fromtheNationalInstituteofMentalHealth,Be¬ thesda, Md. Theauthorswish to acknowledge the critical contribu¬ tionstothisresearchprogrammadebytheclinicalandre¬ searchstaffsoftheNeuropsychiatrieStudiesUnitandtheBi¬ ologicalStudiesUnit,WestHavenVeteransAffairsMedical Center,andtheClinicalNeuroscienceResearchUnit,Con¬ necticutMentalHealthCenter.GlennaFreemanandDor¬ othy Soliwoda assisted with gathering of data for prepa¬the rationoftablesforthisreport.PedroMendiaassistedwith statisticalanalyses. ReprintrequeststoSchizophreniaBiologicalResearchCen¬ ter,DepartmentofPsychiatry,YaleUniversitySchoolofMed¬ icine,AffairsWestHavenVeteransMedicalCenter,WestHa¬ ven,Conn06516(DrKrystal).

PY - 1993/8

Y1 - 1993/8

UR - http://www.scopus.com/inward/record.url?scp=0027296447&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.1993.01820200034004

DO - 10.1001/archpsyc.1993.01820200034004

M3 - Article

C2 - 8102048

AN - SCOPUS:0027296447

SN - 0003-990X

VL - 50

SP - 624

EP - 635

JO - Archives of General Psychiatry

JF - Archives of General Psychiatry

IS - 8

ER -