Abstract
Hypertension induces hypertrophy and increased turnover of aortic smooth muscle cells along with an accumulation of connective tissue in the aortic wall. The lysosomes in normal and hypertensive aortic muscle cells were identified by light and electron microscopy, utilizing cytochemical staining for acid phosphatase activity. Lysosomes were found to be more numerous in hypertensive vessels. Biochemical assays of two specific lysosomal enzymes revealed a doubling of acid phosphatase and a more than threefold increase in β N acetyl glucosaminidase activities in hypertensive aortas.
| Original language | English |
|---|---|
| Pages (from-to) | 727-734 |
| Number of pages | 8 |
| Journal | American Journal of Pathology |
| Volume | 73 |
| Issue number | 3 |
| State | Published - 1973 |
| Externally published | Yes |