Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy

Saghi Ghaffari

doi:10.1016/j.stem.2021.02.017

Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy

Saghi Ghaffari

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.

Original language	English
Pages (from-to)	374-377
Number of pages	4
Journal	Cell Stem Cell
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.stem.2021.02.017
State	Published - 4 Mar 2021

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title = "Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy",

abstract = "The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.",

author = "Saghi Ghaffari",

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AB - The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.

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JF - Cell Stem Cell

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Lysosomal Regulation of Metabolism in Quiescent Hematopoietic Stem Cells: More than Just Autophagy

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