Lymphomatoid Papulosis with Antigen Deletion and Clonal Rearrangement in a 4‐Year‐Old Boy

Judith Hellman, Robert G. Phelps, Jim Baral, Thomas M. Fasy, Caitlin M. Ahern, James A. Strauchen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Lymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4‐year‐old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD‐8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor β gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long‐term observation is cruciai, especially in chiidren. We recommend routine clonal rearrangement studies for aid in diagnosis and follow‐up, and as possible prognostic indicators in children with this condition.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalPediatric Dermatology
Volume7
Issue number1
DOIs
StatePublished - Mar 1990

Fingerprint

Dive into the research topics of 'Lymphomatoid Papulosis with Antigen Deletion and Clonal Rearrangement in a 4‐Year‐Old Boy'. Together they form a unique fingerprint.

Cite this