Abstract
Lymphomatoid papulosis (LyP) is rarely seen in children. We report a case of LyP in a 4‐year‐old boy in whom immunopathologic studies demonstrated T cell antigen deletions. In contrast to all but two previous reports, a T suppressor (CD‐8) phenotype was predominant. Southern blot analysis of DNA isolated from a typical skin lesion indicated a clonal rearrangement of the T cell receptor β gene. Because of a 10% frequency of malignant lymphomas in patients with LyP, long‐term observation is cruciai, especially in chiidren. We recommend routine clonal rearrangement studies for aid in diagnosis and follow‐up, and as possible prognostic indicators in children with this condition.
Original language | English |
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Pages (from-to) | 42-47 |
Number of pages | 6 |
Journal | Pediatric Dermatology |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1990 |