TY - JOUR
T1 - Lymphoma risk and occupational exposure to pesticides
T2 - Results of the Epilymph study
AU - Cocco, Pierluigi
AU - Satta, Giannina
AU - Dubois, Stefania
AU - Pili, Claudia
AU - Pilleri, Michela
AU - Zucca, Mariagrazia
AU - Mannetje, Andrea Martine t.
AU - Becker, Nikolaus
AU - Benavente, Yolanda
AU - De Sanjosé, Silvia
AU - Foretova, Lenka
AU - Staines, Anthony
AU - Maynadié, Marc
AU - Nieters, Alexandra
AU - Brennan, Paul
AU - Miligi, Lucia
AU - Ennas, Maria Grazia
AU - Boffetta, Paolo
PY - 2013/2
Y1 - 2013/2
N2 - Objectives: We investigated the role of occupational exposure to specific groups of agrochemicals in the aetiology of lymphoma overall, B cell lymphoma and its most prevalent subtypes. Methods: In 1998-2003, 2348 incident lymphoma cases and 2462 controls were recruited to the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Job modules were applied for farm work including specific questions on type of crop, farm size, pests being treated, type and schedule of pesticide use. In each study centre, industrial hygienists and occupational experts assessed exposure to specific groups of pesticides and individual compounds with the aid of agronomists. We calculated the OR and its 95% CI associated with lymphoma and the most prevalent lymphoma subtypes with unconditional logistic regression, adjusting for age, gender, education and centre. Results: Risk of lymphoma overall, and B cell lymphoma was not elevated, and risk of chronic lymphocytic leukaemia (CLL) was elevated amongst those ever exposed to inorganic (OR=1.6, 95% CI 1.0 to 2.5) and organic pesticides (OR=1.5, 95% CI 1.0 to 2.1). CLL risk was highest amongst those ever exposed to organophosphates (OR=2.7, 95% CI 1.2 to 6.0). Restricting the analysis to subjects most likely exposed, no association was observed between pesticide use and risk of B cell lymphoma. Conclusions: Our results provide limited support to the hypothesis of an increase in risk of specific lymphoma subtypes associated with exposure to pesticides.
AB - Objectives: We investigated the role of occupational exposure to specific groups of agrochemicals in the aetiology of lymphoma overall, B cell lymphoma and its most prevalent subtypes. Methods: In 1998-2003, 2348 incident lymphoma cases and 2462 controls were recruited to the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls. Job modules were applied for farm work including specific questions on type of crop, farm size, pests being treated, type and schedule of pesticide use. In each study centre, industrial hygienists and occupational experts assessed exposure to specific groups of pesticides and individual compounds with the aid of agronomists. We calculated the OR and its 95% CI associated with lymphoma and the most prevalent lymphoma subtypes with unconditional logistic regression, adjusting for age, gender, education and centre. Results: Risk of lymphoma overall, and B cell lymphoma was not elevated, and risk of chronic lymphocytic leukaemia (CLL) was elevated amongst those ever exposed to inorganic (OR=1.6, 95% CI 1.0 to 2.5) and organic pesticides (OR=1.5, 95% CI 1.0 to 2.1). CLL risk was highest amongst those ever exposed to organophosphates (OR=2.7, 95% CI 1.2 to 6.0). Restricting the analysis to subjects most likely exposed, no association was observed between pesticide use and risk of B cell lymphoma. Conclusions: Our results provide limited support to the hypothesis of an increase in risk of specific lymphoma subtypes associated with exposure to pesticides.
UR - http://www.scopus.com/inward/record.url?scp=84872807679&partnerID=8YFLogxK
U2 - 10.1136/oemed-2012-100845
DO - 10.1136/oemed-2012-100845
M3 - Article
C2 - 23117219
AN - SCOPUS:84872807679
SN - 1351-0711
VL - 70
SP - 91
EP - 98
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
IS - 2
ER -