Lymphoma immunotherapy: Vaccines, adoptive cell transfer and immunotransplant

Joshua Brody, Ronald Levy

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Therapy for non-Hodgkin lymphoma has benefited greatly from basic science and clinical research such that chemotherapy and monoclonal antibody therapy have changed some lymphoma subtypes from uniformly lethal to curable, but the majority of lymphoma patients remain incurable. Novel therapies with less toxicity and more specific targeting of tumor cells are needed and immunotherapy is among the most promising of these. Recently completed randomized trials of idiotype vaccines and earlier-phase trials of other vaccine types have shown the ability to induce antitumor T cells and some clinical responses. More recently, trials of adoptive transfer of antitumor T cells have demonstrated techniques to increase the persistence and antitumor effect of these cells. Herein, we discuss lymphoma immunotherapy clinical trial results and what lessons can be taken to improve their effect, including the combination of vaccination and adoptive transfer in an approach we have dubbed 'immunotransplant'.

Original languageEnglish
Pages (from-to)809-824
Number of pages16
JournalImmunotherapy
Volume1
Issue number5
DOIs
StatePublished - Sep 2009
Externally publishedYes

Keywords

  • Adoptive transfer
  • Chimeric antigen receptor
  • Clinical trial
  • Dendritic cell
  • Idiotype immunotherapy
  • Immunotransplant
  • Lymphoma
  • Vaccine

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