TY - JOUR
T1 - Lymphocyte subpopulations in immunodeficiency disorders. I. Human thymus-lymphoid tissue antigen
AU - Yata, J.
AU - Gatti, R. A.
AU - Klein, G.
AU - Good, R. A.
AU - Tsukimoto, I.
N1 - Funding Information:
This work was supported by a cancer research subsidy from the Japanese Ministry of Health Welfare, the Swedish Cancer Society, the National Foundation-March of Dimes, the American Heart Association, US Public Health Service (A108677, AIOO798), NIH Contract 071-2261, and NIH-NC1 Contract E-69-2005.
PY - 1974/7
Y1 - 1974/7
N2 - Peripheral blood lymphocytes from 25 normal persons and 47 patients with immunodeficiency diseases were studied for the presence of human thymus-lymphoid tissue antigen (HTLA) and their responsiveness to PHA. Whereas in normal persons, HTLA values were consistently around 36%, 17 immunodeficient patients had low numbers of HTLA-positive lymphocytes in their peripheral blood. In general, HTLA values corresponded with PHA responsiveness ( 36 47), however, a number of discordant situations were observed. These results suggest that HTLA may be a useful marker in evaluating an immunologically relevant lymphocyte population in clinical situations. This population is most likely of thymus origin (4,5) and appears to be associated with PHA responsiveness in most situations. On the other hand, the dissociation of these markers in 11 patients suggests that they detect either distinct but overlapping populations, different phases of differentiation of a single lymphocyte population or that the cells involved may be perturbed independently by exogenous factors, such as infections.
AB - Peripheral blood lymphocytes from 25 normal persons and 47 patients with immunodeficiency diseases were studied for the presence of human thymus-lymphoid tissue antigen (HTLA) and their responsiveness to PHA. Whereas in normal persons, HTLA values were consistently around 36%, 17 immunodeficient patients had low numbers of HTLA-positive lymphocytes in their peripheral blood. In general, HTLA values corresponded with PHA responsiveness ( 36 47), however, a number of discordant situations were observed. These results suggest that HTLA may be a useful marker in evaluating an immunologically relevant lymphocyte population in clinical situations. This population is most likely of thymus origin (4,5) and appears to be associated with PHA responsiveness in most situations. On the other hand, the dissociation of these markers in 11 patients suggests that they detect either distinct but overlapping populations, different phases of differentiation of a single lymphocyte population or that the cells involved may be perturbed independently by exogenous factors, such as infections.
UR - https://www.scopus.com/pages/publications/0016222624
U2 - 10.1016/0090-1229(74)90070-1
DO - 10.1016/0090-1229(74)90070-1
M3 - Article
AN - SCOPUS:0016222624
SN - 0090-1229
VL - 2
SP - 519
EP - 525
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 4
ER -