Lymphocyte Function in Major Depressive Disorder

Steven J. Schleifer, Steven E. Keller, Arthur T. Meyerson, Marjorie J. Raskin, Kenneth L. Davis, Marvin Stein

Research output: Contribution to journalArticlepeer-review

303 Scopus citations


Lymphocyte stimulation by phytohemagglutinin, concanavalin A, and pokeweed mitogen was significantly lower in a group of hospitalized depressed patients than in matched controls. The absolute number of T and B cells was lower in the depressed group, but the percentage of these cell types did not differ between the groups. These findings may be related to the altered neuroendocrine function found in patients with depressive disorders.

Original languageEnglish
Pages (from-to)484-486
Number of pages3
JournalArchives of General Psychiatry
Issue number5
StatePublished - May 1984
Externally publishedYes


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