Lymphoblastic Lymphoma

Birgit Burkhardt, Birte Wistinghausen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Lymphoblastic lymphoma (LBL) is the second most common type of non-Hodgkin lymphoma (NHL) in childhood and adolescence accounting for 25-35% of all cases. The majority, 70-80%, is of T-lymphoblastic origin, and 20-25% arise from B-lymphoblasts. With intensification of therapy in the last decades, the event-free and overall survivals for pediatric LBL patients are now exceeding 80%, but the burden of therapy causes considerable morbidity and late sequela. In addition, the prognosis of relapsed patients remains poor (Schmidt and Burkhardt. Pediatr Hematol Oncol. 30:484-508, 2013). This chapter will focus on the pathogenesis and biology of LBL, recent advances in the therapy of LBL, and ongoing and future efforts in optimizing therapy and developing novel targeted treatment approaches.

Original languageEnglish
Title of host publicationNon-Hodgkin’s Lymphoma in Childhood and Adolescence
PublisherSpringer International Publishing
Pages153-164
Number of pages12
ISBN (Electronic)9783030117696
ISBN (Print)9783030117689
DOIs
StatePublished - 1 Jan 2019
Externally publishedYes

Keywords

  • Adolescents
  • Children
  • Lymphoblastic lymphoma
  • Precursor b cell
  • Precursor t cell

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