Luteal phase deficiency after completely normal follicular and periovulatory phases

L. Grunfeld, B. Sandler, J. Fox, C. Boyd, P. Kaplan, D. Navot

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Luteal phase defect (LPD) accounts for a significant proportion of reproductive disorders, however its etiology is still debated. A prospective study was performed on 37 ovulatory women to determine whether LPD can occur in cycles characterized by completely normal folliculogenesis. Criteria for normal folliculogenesis included: a gradual rise of serum estradiol, a luteinizing hormone (LH) surge, the presence of a dominant follicle that disappeared, an increase of serum progesterone, and normal serum levels of prolactin, testosterone, dehydroepiandrosterone sulfate, follicle-stimulating hormone, and LH. Thirty of 37 women fulfilled the above mentioned strict criteria and underwent endometrial biopsy in the late luteal phase. Seven of 30 (23%) demonstrated a delay in endometrial development and all had normal hormonal and ultrasonographic parameters of folliculogenesis and ovulation. Women with delayed endometrial development demonstrated slightly longer follicular phases (17.0 ± 1.1 versus 14.5 ± 0.3 days). Perfectly normal follicular and periovulatory events may be followed by deficient luteal phases.

Original languageEnglish
Pages (from-to)919-923
Number of pages5
JournalFertility and Sterility
Issue number6
StatePublished - 1989


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