Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

Wei Zheng; Hui Zhang; Dejian Zhao; Jinghang Zhang; Jeffrey W. Pollard

doi:10.1016/j.celrep.2019.10.016

Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

Wei Zheng, Hui Zhang, Dejian Zhao, Jinghang Zhang, Jeffrey W. Pollard

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Zheng et al. show a distinct type of large platelets is specifically enriched in lung metastases but not in primary tumors. Identification of this cell type provides insight into the complexity of the metastatic tumor microenvironment. It also helps clarify confusion about the origin of endothelial progenitor cells.

Original language	English
Pages (from-to)	1747-1755.e4
Journal	Cell Reports
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2019.10.016
State	Published - 12 Nov 2019
Externally published	Yes

Keywords

angiogenesis
breast cancer
chemokines
endothelial progenitor cells
megakaryocytes
metastasis
platelets
tumor microenvironment

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10.1016/j.celrep.2019.10.016

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title = "Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression",

abstract = "Zheng et al. show a distinct type of large platelets is specifically enriched in lung metastases but not in primary tumors. Identification of this cell type provides insight into the complexity of the metastatic tumor microenvironment. It also helps clarify confusion about the origin of endothelial progenitor cells.",

keywords = "angiogenesis, breast cancer, chemokines, endothelial progenitor cells, megakaryocytes, metastasis, platelets, tumor microenvironment",

author = "Wei Zheng and Hui Zhang and Dejian Zhao and Jinghang Zhang and Pollard, {Jeffrey W.}",

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AU - Zheng, Wei

AU - Zhang, Hui

AU - Zhao, Dejian

AU - Zhang, Jinghang

AU - Pollard, Jeffrey W.

PY - 2019/11/12

Y1 - 2019/11/12

N2 - Zheng et al. show a distinct type of large platelets is specifically enriched in lung metastases but not in primary tumors. Identification of this cell type provides insight into the complexity of the metastatic tumor microenvironment. It also helps clarify confusion about the origin of endothelial progenitor cells.

AB - Zheng et al. show a distinct type of large platelets is specifically enriched in lung metastases but not in primary tumors. Identification of this cell type provides insight into the complexity of the metastatic tumor microenvironment. It also helps clarify confusion about the origin of endothelial progenitor cells.

KW - angiogenesis

KW - breast cancer

KW - chemokines

KW - endothelial progenitor cells

KW - megakaryocytes

KW - metastasis

KW - platelets

KW - tumor microenvironment

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JF - Cell Reports

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ER -

Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

Abstract

Keywords

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