Lung cancer risk attributable to occupational exposures in a multicenter case-control study in central and Eastern Europe

Ann C. Olsson, Per Gustavsson, David Zaridze, Anush Mukeriya, Neonila Szeszenia-Dabrowska, Peter Rudnai, Jolanta Lissowska, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Joelle Fevotte, Andrea 'T Mannetje, Tony Fletcher, Paul Brennan, Paolo Boffetta

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Objective: To estimate the lung cancer risk attributable to occupational lung carcinogens. METHODS: Information was collected through interviews from 2624 newly diagnosed lung cancer cases and 2690 frequency-matched controls in Central and Eastern Europe. Industrial hygiene experts evaluated exposure to 70 occupational agents. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression and attributable fractions (AF) by Miettinens formula. RESULTS: Exposure to at least one occupational lung carcinogen resulted in an AF of 7.9% in men and 1.4% in women. Metals and silica contributed the most to the AF. The AF was highest for squamous cell carcinoma among men (11.4%) and for small cell carcinoma among women (7.1%); the effect of occupational lung carcinogens was stronger overall among current smokers. CONCLUSION: This estimation of the AF of occupational lung carcinogens is comparable to that estimated in other European studies, and cannot alone explain the high lung cancer rates in Central and Eastern Europe.

Original languageEnglish
Pages (from-to)1262-1267
Number of pages6
JournalJournal of Occupational and Environmental Medicine
Volume53
Issue number11
DOIs
StatePublished - Nov 2011

Fingerprint

Dive into the research topics of 'Lung cancer risk attributable to occupational exposures in a multicenter case-control study in central and Eastern Europe'. Together they form a unique fingerprint.

Cite this