TY - JOUR
T1 - Lung cancer and socioeconomic status in a pooled analysis of case-control studies
AU - Hovanec, Jan
AU - Siemiatycki, Jack
AU - Conway, David I.
AU - Olsson, Ann
AU - Stücker, Isabelle
AU - Guida, Florence
AU - Jockel, Karl Heinz
AU - Pohlabeln, Hermann
AU - Ahrens, Wolfgang
AU - Brüske, Irene
AU - Wichmann, Heinz Erich
AU - Gustavsson, Per
AU - Consonni, Dario
AU - Merletti, Franco
AU - Richiardi, Lorenzo
AU - Simonato, Lorenzo
AU - Fortes, Cristina
AU - Parent, Marie Elise
AU - McLaughlin, John
AU - Demers, Paul
AU - Landi, Maria Teresa
AU - Caporaso, Neil
AU - Tardón, Adonina
AU - Zaridze, David
AU - Szeszenia-Dabrowska, Neonila
AU - Rudnai, Peter
AU - Lissowska, Jolanta
AU - Fabianova, Eleonora
AU - Field, John
AU - Dumitru, Rodica Stanescu
AU - Bencko, Vladimir
AU - Foretova, Lenka
AU - Janout, Vladimir
AU - Kromhout, Hans
AU - Vermeulen, Roel
AU - Boffetta, Paolo
AU - Straif, Kurt
AU - Schüz, Joachim
AU - Kendzia, Benjamin
AU - Pesch, Beate
AU - Brüning, Thomas
AU - Behrens, Thomas
N1 - Funding Information:
This study was supported by the German Social Accident Insurance, grant number FP 271. Grant sponsors of the individual studies were the Canadian Institutes for Health Research and Guzzo-SRC Chair in Environment and Cancer, National Cancer Institute of Canada, Canadian Cancer Society, Occupational Cancer Research Centre, Workplace Safety and Insurance Board, Canadian Cancer Society, and Cancer Care Ontario; Grant sponsor: European Commission's INCO Copernicus program; Grant number: IC15-CT96-0313; Grant sponsor: European Union Nuclear Fission Safety Program; Grant number: F14P-CT96-0055; Grant sponsors: French Agency of Health Security (ANSES), Fondation de France, French National Research Agency (ANR), National Institute of Cancer (INCA), Fondation pour la Recherche Medicale, French Institute for Public Health Surveillance (InVS), Health Ministry (DGS), Organization for the Research on Cancer (ARC), and French Ministry of work, solidarity, and public function (DGT); Grant sponsor: Federal Ministry of Education, Science, Research, and Technology; Grant number: 01 HK 173/0); Grant sponsor: Federal Ministry of Science; Grant number: 01 HK 546/8; Grant sponsor: Ministry of Labour and Social Affairs; Grant number: IIIb7-27/13; Grant sponsor: Research Grants Council of the Hong Kong Special Administrative Region, China; Grant number: CUHK4460/03M; Grant sponsors: Environmental Epidemiology Program of the Lombardy Region, INAIL, Italian Association for Cancer Research, Region Piedmont, Compagnia di San Paolo, Lazio Region, Health Research Council of New Zealand, New Zealand Department of Labour, Lottery Health Research, Cancer Society of New Zealand; Grant sponsor: Polish State Committee for Scientific Research; Grant number: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000; Grant sponsors: Instituto Universitario de Oncologia, Universidad de Oviedo, Asturias, Fondo de Investigacion Sanitaria (FIS) and Ciber de Epidemiologia y Salud Publica (CIBERESP), Swedish Council for Work Life Research and Swedish Environmental Protection Agency, Dutch Ministry of Health, Welfare and Sports, National Institute of Public Health and the Environment, and Europe Against Cancer Program, Roy Castle Foundation, and Intramural Research Program of the National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, Maryland.
Funding Information:
SRCChairinEnvironmentandCancer,National CancerInstituteofCanada,CanadianCancer Society,OccupationalCancerResearchCentre, WorkplaceSafetyandInsuranceBoard,Canadian CancerSociety,andCancerCareOntario;Grant sponsor:EuropeanCommission’sINCO Copernicusprogram;Grantnumber:IC15-CT96-0313;Grantsponsor:EuropeanUnionNuclear FissionSafetyProgram;Grantnumber:F14PCT96-0055;Grantsponsors:FrenchAgencyof HealthSecurity(ANSES),FondationdeFrance, FrenchNationalResearchAgency(ANR),National InstituteofCancer(INCA),Fondationpourla RechercheMedicale,FrenchInstituteforPublic HealthSurveillance(InVS),HealthMinistry(DGS), OrganizationfortheResearchonCancer(ARC), andFrenchMinistryofwork,solidarity,andpublic function(DGT);Grantsponsor:FederalMinistryof Education,Science,Research,andTechnology; Grantnumber:01HK173/0);Grantsponsor: FederalMinistryofScience;Grantnumber:01HK 546/8;Grantsponsor:MinistryofLabourand SocialAffairs;Grantnumber:IIIb7-27/13;Grant sponsor:ResearchGrantsCounciloftheHong KongSpecialAdministrativeRegion,China;Grant number:CUHK4460/03M;Grantsponsors: EnvironmentalEpidemiologyProgramofthe LombardyRegion,INAIL,ItalianAssociationfor CancerResearch,RegionPiedmont,Compagniadi SanPaolo,LazioRegion,HealthResearchCouncil ofNewZealand,NewZealandDepartmentof Labour,LotteryHealthResearch,CancerSocietyof NewZealand;Grantsponsor:PolishState CommitteeforScientificResearch;Grantnumber: SPUB-M-COPERNICUS/P-05/DZ-30/99/2000; Grantsponsors:InstitutoUniversitariode Oncologia,UniversidaddeOviedo,Asturias,Fondo deInvestigacionSanitaria(FIS)andCiberde EpidemiologiaySaludPublica(CIBERESP), SwedishCouncilforWorkLifeResearchand SwedishEnvironmentalProtectionAgency,Dutch MinistryofHealth,WelfareandSports,National InstituteofPublicHealthandtheEnvironment,and EuropeAgainstCancerProgram,RoyCastle Foundation,andIntramuralResearchProgramof theNationalInstitutesofHealth,NationalCancer Institute,DivisionofCancerEpidemiologyand Genetics,Bethesda,Maryland.
PY - 2018/2
Y1 - 2018/2
N2 - Background: An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. Methods: Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens. Results: The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61-2.09); ESeC OR 1.53 (95% CI 1.44-1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20-1.98); ESeC OR 1.34 (95% CI 1.19-1.52)). Conclusion: SES remained a risk factor for lung cancer after adjustment for smoking behavior.
AB - Background: An association between low socioeconomic status (SES) and lung cancer has been observed in several studies, but often without adequate control for smoking behavior. We studied the association between lung cancer and occupationally derived SES, using data from the international pooled SYNERGY study. Methods: Twelve case-control studies from Europe and Canada were included in the analysis. Based on occupational histories of study participants we measured SES using the International Socio-Economic Index of Occupational Status (ISEI) and the European Socio-economic Classification (ESeC). We divided the ISEI range into categories, using various criteria. Stratifying by gender, we calculated odds ratios (OR) and 95% confidence intervals (CI) by unconditional logistic regression, adjusting for age, study, and smoking behavior. We conducted analyses by histological subtypes of lung cancer and subgroup analyses by study region, birth cohort, education and occupational exposure to known lung carcinogens. Results: The analysis dataset included 17,021 cases and 20,885 controls. There was a strong elevated OR between lung cancer and low SES, which was attenuated substantially after adjustment for smoking, however a social gradient persisted. SES differences in lung cancer risk were higher among men (lowest vs. highest SES category: ISEI OR 1.84 (95% CI 1.61-2.09); ESeC OR 1.53 (95% CI 1.44-1.63)), than among women (lowest vs. highest SES category: ISEI OR 1.54 (95% CI 1.20-1.98); ESeC OR 1.34 (95% CI 1.19-1.52)). Conclusion: SES remained a risk factor for lung cancer after adjustment for smoking behavior.
UR - http://www.scopus.com/inward/record.url?scp=85042607215&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0192999
DO - 10.1371/journal.pone.0192999
M3 - Article
C2 - 29462211
AN - SCOPUS:85042607215
SN - 1932-6203
VL - 13
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e0192999
ER -