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LRRK2 and Parkinson’s disease: From lack of structure to gain of function
Marian Blanca Ramírez
, Jesús Madero-Pérez
, Pilar Rivero-Ríos
, Mar Martínez-Salvador
, Antonio Jesús Lara Ordóñez
, Belén Fernández
, Elena Fdez
, Sabine Hilfiker
Research output
:
Contribution to journal
›
Review article
›
peer-review
16
Scopus citations
Overview
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Dive into the research topics of 'LRRK2 and Parkinson’s disease: From lack of structure to gain of function'. Together they form a unique fingerprint.
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Keyphrases
Parkinson's Disease
100%
Leucine-rich Repeat Kinase 2 (LRRK2)
100%
Gain-of-function
100%
Type-specific
25%
Increased Activity
12%
Most Common Cause
12%
Kinase Activity
12%
Kinase Inhibitor
12%
Catalytic Activity
12%
Drug Development
12%
Expressed Protein
12%
Large Proteins
12%
Disease Spectrum
12%
Kinase Domain
12%
Development Approach
12%
Sporadic Disease
12%
Idiopathic Parkinson's Disease
12%
Pathogenic mutations
12%
Biochemical Activity
12%
GTPase Domain
12%
Non-neuronal Tissues
12%
Liability Issues
12%
LRRK2 Kinase Inhibitor
12%
Medicine and Dentistry
Phosphotransferase
100%
Parkinson's Disease
100%
Phosphotransferase Inhibitor
100%
Diseases
100%
Guanosine Triphosphatase
50%
Familial Parkinson's Disease
50%
Pharmacology, Toxicology and Pharmaceutical Science
Phosphotransferase
100%
Parkinson's Disease
100%
Phosphotransferase Inhibitor
100%
Diseases
100%
Drug Development
50%
Guanosine Triphosphatase
50%