Low spinal and pelvic bone mineral density among individuals with Down syndrome

D. Sepulveda, D. B. Allison, J. E. Gomez, K. Kreibich, R. A. Brown, R. N. Pierson, S. B. Heymsfield

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The bone mineral density of 15 adults with Down syndrome was compared to 25 control subjects without Down syndrome. Bone mineral density was measured by dual x-ray absorptiometry with a Lunar DPX(TM) scanner. Arm, leg, pelvic, and spine bone mineral density was tested. Analysis of covariance was conducted for each variable; Down syndrome was the independent variable, and the covariates were height, lean body mass, fat mass, age, and gender. No significant group differences were found for arm or leg bone mineral density. Individuals with Down syndrome had significantly lower pelvic and spinal bone mineral density. Before adjustment for covariates, percentage difference between group means for spine was 14.5% and for pelvis, 11.6%. Adjusted percentage was 11.1% and 13.9%, respectively. Suggestions for further research were made.

Original languageEnglish
Pages (from-to)109-114
Number of pages6
JournalAmerican Journal on Mental Retardation
Issue number2
StatePublished - 1995
Externally publishedYes


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