TY - JOUR
T1 - Low-Flow cardiopulmonary bypass and cerebral protection
T2 - A summary of investigations
AU - Swain, Julie A.
AU - Anderson, Richard V.
AU - Siegman, Michael G.
PY - 1993/12
Y1 - 1993/12
N2 - A research program in cerebral ischemia was initiated by our laboratory to determine optimal strategies for cerebroprotection. Four studies relating to cerebroprotection using nuclear magnetic resonance spectroscopy in a sheep model of hypothermic cardiopulmonary bypass are summarized. These showed, first, that low-flow bypass, with a flow as low as 10 mL · kg-1 · min-1, maintained normal cerebral metabolism; second, that hypothermia increases the high-energy phosphate content and the intracellular pH of the train; third, that hyperglycemia causes a profound intracellular acidosis; and, finally, that barbiturates prevent the normal increase in high-energy phosphates associated with hypothermia.
AB - A research program in cerebral ischemia was initiated by our laboratory to determine optimal strategies for cerebroprotection. Four studies relating to cerebroprotection using nuclear magnetic resonance spectroscopy in a sheep model of hypothermic cardiopulmonary bypass are summarized. These showed, first, that low-flow bypass, with a flow as low as 10 mL · kg-1 · min-1, maintained normal cerebral metabolism; second, that hypothermia increases the high-energy phosphate content and the intracellular pH of the train; third, that hyperglycemia causes a profound intracellular acidosis; and, finally, that barbiturates prevent the normal increase in high-energy phosphates associated with hypothermia.
UR - https://www.scopus.com/pages/publications/0027752744
U2 - 10.1016/0003-4975(93)90737-3
DO - 10.1016/0003-4975(93)90737-3
M3 - Article
C2 - 8267475
AN - SCOPUS:0027752744
SN - 0003-4975
VL - 56
SP - 1490
EP - 1492
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 6
ER -