Low energy conversion of atrial fibrillation in the sheep

Anne C. Powell, Hasan Garan, Brian A. McGovern, John T. Fallon, Subramaniam C. Krishnan, Jeremy N. Ruskin

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Objectives. In this study, the feasibility, efficacy and safety of low energy internal atrial cardioversion were investigated in a sheep model. The relation between the level of energy used for atrial defibrillation and the probability of successful cardioversion was examined. Background. Atrial fibrillation is a common clinical arrhythmia that frequently recurs after termination with high energy external cardioversion. In some patients with drug-refractory and poorly tolerated atrial fibrillation, an automatic implantable cardioverter may prove useful by providing rapid restoration of sinus rhythm. Methods. In 16 pentobarbital-anesthetized sheep, a right atrial spring electrode was implanted percutaneously and a left thoracic cutaneous patch electrode was placed on the thorax. Sustained atrial fibrillation was induced by rapid atrial pacing and terminated by biphasic cathodal shocks synchronized to the R wave of the surface electrocardiogram (ECG). Results. During 768 defibrillation attempts in 16 sheep, the percent of successful cardioversion attempts increased in a doseresponse manner, reaching a plateau at the average energy level of 5 J. With ≥ 1.5 and ≥ 2.5 J energy levels, cardioversion was achieved, respectively, in > 50% and > 80% of attempts. Ventricular fibrillation occurred in 18 (2.4%) of 768 cardioversion attempts; in all 18 cases, the shock was poorly synchronized with the ECG R wave. Conclusions. Low energy cardioversion of atrial fibrillation to sinus rhythm is feasible with use of a right atrial spring/cutaneous patch electrode configuration. The percent of successful cardioversion attempts depends on the level of energy output, and there is a risk of ventricular fibrillation if cardioversion is poorly synchronized with ventricular depolarization.

Original languageEnglish
Pages (from-to)707-711
Number of pages5
JournalJournal of the American College of Cardiology
Volume20
Issue number3
DOIs
StatePublished - Sep 1992
Externally publishedYes

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