Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis

Seray Demir; Sandra Heckers; Xiomara Pedreiturria; Daniela Hess; Anne Kathrin Trampe; Andrew Chan; Ralf Gold

doi:10.1016/j.jneuroim.2015.05.010

Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis

Seray Demir
, Sandra Heckers
, Xiomara Pedreiturria
, Daniela Hess
, Anne Kathrin Trampe
, Andrew Chan
, Ralf Gold

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway.

Original language	English
Pages (from-to)	16-21
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	285
DOIs	https://doi.org/10.1016/j.jneuroim.2015.05.010
State	Published - 2015
Externally published	Yes

Keywords

Dimethylfumarate
Nrf2
OSE

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10.1016/j.jneuroim.2015.05.010

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title = "Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis",

abstract = "In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway.",

keywords = "Dimethylfumarate, Nrf2, OSE",

author = "Seray Demir and Sandra Heckers and Xiomara Pedreiturria and Daniela Hess and Trampe, \{Anne Kathrin\} and Andrew Chan and Ralf Gold",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

doi = "10.1016/j.jneuroim.2015.05.010",

language = "English",

volume = "285",

pages = "16--21",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

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T1 - Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis

AU - Demir, Seray

AU - Heckers, Sandra

AU - Pedreiturria, Xiomara

AU - Hess, Daniela

AU - Trampe, Anne Kathrin

AU - Chan, Andrew

AU - Gold, Ralf

PY - 2015

Y1 - 2015

N2 - In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway.

AB - In this study we examined the role of fumaric acid esters (FAE) in a spontaneous and chronic animal model, the opticospinal EAE (OSE). Preventive treatment of dimethylfumarate (DMF) promotes onset of disease in animals treated with high dose DMF. This group also exhibited a significantly exacerbated disease course in a therapeutic treatment as compared to the low dose DMF approach, where less demyelination, macrophage infiltration, and increased Nrf2 expression in the spinal cord were observed. We conclude that low dose DMF treatment is effective in the therapy of the spontaneous opticospinal EAE model and mediates neuroprotective effects via the oxidative stress response pathway.

KW - Dimethylfumarate

KW - Nrf2

KW - OSE

UR - https://www.scopus.com/pages/publications/84943239726

U2 - 10.1016/j.jneuroim.2015.05.010

DO - 10.1016/j.jneuroim.2015.05.010

M3 - Article

C2 - 26198914

AN - SCOPUS:84943239726

SN - 0165-5728

VL - 285

SP - 16

EP - 21

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Low dose fumaric acid esters are effective in a mouse model of spontaneous chronic encephalomyelitis

Abstract

Keywords

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