Low cerebellar metabolism in medicated patients with chronic schizophrenia

Nora D. Volkow, Alex Levy, Jonathan D. Brodie, Alfred P. Wolf, Robert Cancro, Peter Van Gelder, Fritz Henn

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Because of the frequent association of cerebellar structural defects with schizophrenia, the authors reanalyzed the metabolic brain images of patients with chronic schizophrenia to assess if they had abnormalities in cerebellar metabolism. They used carbon-11-2-deoxyglucose and positron emission tomography to study 18 medicated patients with chronic schizophrenia and 12 normal comparison subjects. Patients with schizophrenia showed significantly lower absolute and relative metabolism in the cerebellum than normal subjects.

Original languageEnglish
Pages (from-to)686-688
Number of pages3
JournalAmerican Journal of Psychiatry
Volume149
Issue number5
StatePublished - 1992

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