Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion

Michael L. Olson; Erica R.Vander Mause; Sabarinath V. Radhakrishnan; Joshua D. Brody; Aaron P. Rapoport; Alana L. Welm; Djordje Atanackovic; Tim Luetkens

doi:10.1038/s41375-022-01585-2

Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion

Michael L. Olson, Erica R.Vander Mause, Sabarinath V. Radhakrishnan, Joshua D. Brody, Aaron P. Rapoport, Alana L. Welm, Djordje Atanackovic, Tim Luetkens

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Original language	English
Pages (from-to)	1943-1946
Number of pages	4
Journal	Leukemia
Volume	36
Issue number	7
DOIs	https://doi.org/10.1038/s41375-022-01585-2
State	Published - Jul 2022

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10.1038/s41375-022-01585-2

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@article{01ac86184f8749dcb10cbfdf9a652680,

title = "Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion",

author = "Olson, {Michael L.} and Mause, {Erica R.Vander} and Radhakrishnan, {Sabarinath V.} and Brody, {Joshua D.} and Rapoport, {Aaron P.} and Welm, {Alana L.} and Djordje Atanackovic and Tim Luetkens",

note = "Funding Information: American Association of Immunologists Fellowship (MLO and DA), Huntsman Cancer Institute Transitional Scholar Award (DA), Huntsman Cancer Foundation development funds (ALW) and National Comprehensive Cancer Network Young Investigator Award (TL). ",

year = "2022",

month = jul,

doi = "10.1038/s41375-022-01585-2",

language = "English",

volume = "36",

pages = "1943--1946",

journal = "Leukemia",

issn = "0887-6924",

publisher = "Nature Publishing Group",

number = "7",

}

TY - JOUR

T1 - Low-affinity CAR T cells exhibit reduced trogocytosis, preventing rapid antigen loss, and increasing CAR T cell expansion

AU - Olson, Michael L.

AU - Mause, Erica R.Vander

AU - Radhakrishnan, Sabarinath V.

AU - Brody, Joshua D.

AU - Rapoport, Aaron P.

AU - Welm, Alana L.

AU - Atanackovic, Djordje

AU - Luetkens, Tim

N1 - Funding Information: American Association of Immunologists Fellowship (MLO and DA), Huntsman Cancer Institute Transitional Scholar Award (DA), Huntsman Cancer Foundation development funds (ALW) and National Comprehensive Cancer Network Young Investigator Award (TL).

PY - 2022/7

Y1 - 2022/7

UR - http://www.scopus.com/inward/record.url?scp=85129213162&partnerID=8YFLogxK

U2 - 10.1038/s41375-022-01585-2

DO - 10.1038/s41375-022-01585-2

M3 - Article

AN - SCOPUS:85129213162

SN - 0887-6924

VL - 36

SP - 1943

EP - 1946

JO - Leukemia

JF - Leukemia

IS - 7

ER -