Loss of Ku70/Ku80 expression occurs more frequently in hereditary than in sporadic colorectal tumors. Tissue microarray study

Monika Korabiowska, Carlos Cordon-Cardo, Michael Schinagl, Michael Karaus, Jerzy Stachura, Harald Schulz, Gösta Fischer

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Ku70 and Ku80 proteins take part in the repairing of DNA double-strand breaks by their function as a regulatory subunit of the DNA-dependent protein kinase. In this study, expression of both genes was analyzed in colorectal carcinoma tissue arrays applying immunohistochemistry. Expression of both genes decreased along with pT stage. Significant differences in Ku70 and Ku80 expression were found between pT3 and pT4 as well as between pT2 and pT3 tumors, respectively. Loss of Ku70/Ku80 expression was more frequently observed in hereditary than in sporadic tumors. We conclude that expression of Ku70/Ku80 genes is down-regulated in colorectal carcinoma and that defects of these genes are more frequently observed in hereditary than in sporadic tumors.

Original languageEnglish
Pages (from-to)448-452
Number of pages5
JournalHuman Pathology
Volume37
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Keywords

  • Colon cancer
  • Ku70
  • Ku80
  • Tissue array

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