Loracarbef: Sinus tissue penetration after single dose administration

The underlying basis of the antibiotic treatment of sinusitis is still unclear. Critical to the use of antibiotics in patients with sinusitis is the tissue penetration of the curative agent. However, there is scant information available regarding maxillary mucosal tissue levels in patients with this disease. We present the results of plasma and sinus tissue concentrations of loracarbef in six patients and one control. Levels were taken at 2 and 3 hours after the oral administration of the medication. The mean sinus tissue level was 2.5 mcg/gm and 2.7 mcg/gm at 2 and 3 hours after administration respectively. Although therapeutic efficacy cannot be predicted by the concentrations attained in a specific body fluid or tissue, we believe that these levels are excellent based on mean inhibitory concentrations. Additional studies are underway to document the penetration of this and comparable other drugs in multiple sinuses.