Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device

WILLIAM A. ANDERSON; CHARLES R. BRIDGES; ALVIN J. CHIN; JAMES S. ANDERSEN; MICHAEL A. ACKER; ROBERT L. HAMMOND; FREDERICK DIMEO; PATRICK T. CAHALAN; DENNIS R. GALE; WENDY E. BROWN; LARRY W. STEPHENSON

doi:10.1111/j.1540-8159.1988.tb06361.x

Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device

WILLIAM A. ANDERSON
, CHARLES R. BRIDGES
, ALVIN J. CHIN
, JAMES S. ANDERSEN
, MICHAEL A. ACKER
, ROBERT L. HAMMOND
, FREDERICK DIMEO
, PATRICK T. CAHALAN
, DENNIS R. GALE
, WENDY E. BROWN
, LARRY W. STEPHENSON

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Skeletal muscle has a tremendous capacity to adapt. This adaptive phenomenon is seen perhaps to the greatest extent when skeletal muscle is subjected to chronic low frequency stimulation via the motor nerve. There is a decrease in glycolytic enzymes and an increase in oxidotive enzymes, as well as a change in the contractile proteins and an increase in the mitochondrial volume fraction of the muscle fiber. These adaptive changes result in a muscle that is considerably more fatigue‐resistant. Specifically herein, we report on a pneumatic aortic counterpulsator device powered by skeletal muscle. These muscle pumps functioned continuously and pumped blood effectively in tether‐free animals for several weeks.

Original language	English
Pages (from-to)	2128-2134
Number of pages	7
Journal	PACE - Pacing and Clinical Electrophysiology
Volume	11
Issue number	11
DOIs	https://doi.org/10.1111/j.1540-8159.1988.tb06361.x
State	Published - Nov 1988
Externally published	Yes

Keywords

fatigue‐resistance
skeletal muscle
stimulation

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10.1111/j.1540-8159.1988.tb06361.x

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ANDERSON, WILLIAM. A., BRIDGES, CHARLES. R., CHIN, ALVIN. J., ANDERSEN, JAMES. S., ACKER, MICHAEL. A., HAMMOND, ROBERT. L., DIMEO, FREDERICK., CAHALAN, PATRICK. T., GALE, DENNIS. R., BROWN, WENDY. E., & STEPHENSON, LARRY. W. (1988). Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device. PACE - Pacing and Clinical Electrophysiology, 11(11), 2128-2134. https://doi.org/10.1111/j.1540-8159.1988.tb06361.x

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title = "Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device",

abstract = "Skeletal muscle has a tremendous capacity to adapt. This adaptive phenomenon is seen perhaps to the greatest extent when skeletal muscle is subjected to chronic low frequency stimulation via the motor nerve. There is a decrease in glycolytic enzymes and an increase in oxidotive enzymes, as well as a change in the contractile proteins and an increase in the mitochondrial volume fraction of the muscle fiber. These adaptive changes result in a muscle that is considerably more fatigue‐resistant. Specifically herein, we report on a pneumatic aortic counterpulsator device powered by skeletal muscle. These muscle pumps functioned continuously and pumped blood effectively in tether‐free animals for several weeks.",

keywords = "fatigue‐resistance, skeletal muscle, stimulation",

author = "ANDERSON, \{WILLIAM A.\} and BRIDGES, \{CHARLES R.\} and CHIN, \{ALVIN J.\} and ANDERSEN, \{JAMES S.\} and ACKER, \{MICHAEL A.\} and HAMMOND, \{ROBERT L.\} and FREDERICK DIMEO and CAHALAN, \{PATRICK T.\} and GALE, \{DENNIS R.\} and BROWN, \{WENDY E.\} and STEPHENSON, \{LARRY W.\}",

year = "1988",

month = nov,

doi = "10.1111/j.1540-8159.1988.tb06361.x",

language = "English",

volume = "11",

pages = "2128--2134",

journal = "PACE - Pacing and Clinical Electrophysiology",

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publisher = "John Wiley and Sons Inc.",

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ANDERSON, WILLIAMA, BRIDGES, CHARLESR, CHIN, ALVINJ, ANDERSEN, JAMESS, ACKER, MICHAELA, HAMMOND, ROBERTL, DIMEO, FREDERICK, CAHALAN, PATRICKT, GALE, DENNISR, BROWN, WENDYE & STEPHENSON, LARRYW 1988, 'Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device', PACE - Pacing and Clinical Electrophysiology, vol. 11, no. 11, pp. 2128-2134. https://doi.org/10.1111/j.1540-8159.1988.tb06361.x

TY - JOUR

T1 - Long‐Term Neurostimulation of Skeletal Muscle

T2 - Its Potential for a Tether‐Free Biologic Cardiac Assist Device

AU - ANDERSON, WILLIAM A.

AU - BRIDGES, CHARLES R.

AU - CHIN, ALVIN J.

AU - ANDERSEN, JAMES S.

AU - ACKER, MICHAEL A.

AU - HAMMOND, ROBERT L.

AU - DIMEO, FREDERICK

AU - CAHALAN, PATRICK T.

AU - GALE, DENNIS R.

AU - BROWN, WENDY E.

AU - STEPHENSON, LARRY W.

PY - 1988/11

Y1 - 1988/11

N2 - Skeletal muscle has a tremendous capacity to adapt. This adaptive phenomenon is seen perhaps to the greatest extent when skeletal muscle is subjected to chronic low frequency stimulation via the motor nerve. There is a decrease in glycolytic enzymes and an increase in oxidotive enzymes, as well as a change in the contractile proteins and an increase in the mitochondrial volume fraction of the muscle fiber. These adaptive changes result in a muscle that is considerably more fatigue‐resistant. Specifically herein, we report on a pneumatic aortic counterpulsator device powered by skeletal muscle. These muscle pumps functioned continuously and pumped blood effectively in tether‐free animals for several weeks.

AB - Skeletal muscle has a tremendous capacity to adapt. This adaptive phenomenon is seen perhaps to the greatest extent when skeletal muscle is subjected to chronic low frequency stimulation via the motor nerve. There is a decrease in glycolytic enzymes and an increase in oxidotive enzymes, as well as a change in the contractile proteins and an increase in the mitochondrial volume fraction of the muscle fiber. These adaptive changes result in a muscle that is considerably more fatigue‐resistant. Specifically herein, we report on a pneumatic aortic counterpulsator device powered by skeletal muscle. These muscle pumps functioned continuously and pumped blood effectively in tether‐free animals for several weeks.

KW - fatigue‐resistance

KW - skeletal muscle

KW - stimulation

UR - https://www.scopus.com/pages/publications/0024207384

U2 - 10.1111/j.1540-8159.1988.tb06361.x

DO - 10.1111/j.1540-8159.1988.tb06361.x

M3 - Article

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AN - SCOPUS:0024207384

SN - 0147-8389

VL - 11

SP - 2128

EP - 2134

JO - PACE - Pacing and Clinical Electrophysiology

JF - PACE - Pacing and Clinical Electrophysiology

IS - 11

ER -

Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device

Abstract

Keywords

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