Longitudinal study of serum antibody response to bovine corneal protein (BCP 54) in Behcet's disease

A. S. Kong, W. L. Henley, M. H. Luntz

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8 Scopus citations

Abstract

Serum samples from a patient diagnosed as having Behcet's syndrome with iritis were evaluated by the enzyme-linked immunosorbent assay for antibodies against a purified bovine corneal protein, molecular weight 54,000 daltons (BCP 54). Significantly elevated antibody levels to BCP 54 were found in all serum samples collected over a 2-year period. Anti-BCP 54 antibody levels remained within a very narrow range, at least twofold higher than those of controls. In contrast, no antibody to retinal S antigen was detected. These results indicate the presence of specific anti-BCP 54 autoantibodies in sera from a Behcet's patient and suggest that autoantibodies may play a role in the etiopathogenesis of uveitis.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalOphthalmic Research
Volume21
Issue number6
DOIs
StatePublished - 1989
Externally publishedYes

Keywords

  • Behcet's disease
  • autoimmunity
  • bovine corneal antigen
  • retinal S antigen
  • serum antibodies

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