Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels

Ki Bum Won; Byoung Kwon Lee; Ran Heo; Hyung Bok Park; Fay Y. Lin; Martin Hadamitzky; Yong Jin Kim; Ji Min Sung; Edoardo Conte; Daniele Andreini; Gianluca Pontone; Matthew J. Budoff; Ilan Gottlieb; Eun Ju Chun; Filippo Cademartiri; Erica Maffei; Hugo Marques; Pedro de Araújo Gonçalves; Jonathon A. Leipsic; Sang Eun Lee; Sanghoon Shin; Jung Hyun Choi; Renu Virmani; Habib Samady; Kavitha Chinnaiyan; Daniel S. Berman; Jagat Narula; Jeroen J. Bax; James K. Min; Hyuk Jae Chang

doi:10.1016/j.jacasi.2021.10.010

Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels

Ki Bum Won
, Byoung Kwon Lee
, Ran Heo
, Hyung Bok Park
, Fay Y. Lin
, Martin Hadamitzky
, Yong Jin Kim
, Ji Min Sung
, Edoardo Conte
, Daniele Andreini
, Gianluca Pontone
, Matthew J. Budoff
, Ilan Gottlieb
, Eun Ju Chun
, Filippo Cademartiri
, Erica Maffei
, Hugo Marques
, Pedro de Araújo Gonçalves
, Jonathon A. Leipsic
, Sang Eun Lee

Sanghoon Shin, Jung Hyun Choi, Renu Virmani, Habib Samady, Kavitha Chinnaiyan, Daniel S. Berman, Jagat Narula, Jeroen J. Bax, James K. Min, Hyuk Jae Chang

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm³/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm³) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels.

Original language	English
Pages (from-to)	311-319
Number of pages	9
Journal	JACC: Asia
Volume	2
Issue number	3, Part 2
DOIs	https://doi.org/10.1016/j.jacasi.2021.10.010
State	Published - Jun 2022

Keywords

atherosclerosis
coronary computed tomography angiography
hemoglobin

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10.1016/j.jacasi.2021.10.010

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Won, K. B., Lee, B. K., Heo, R., Park, H. B., Lin, F. Y., Hadamitzky, M., Kim, Y. J., Sung, J. M., Conte, E., Andreini, D., Pontone, G., Budoff, M. J., Gottlieb, I., Chun, E. J., Cademartiri, F., Maffei, E., Marques, H., de Araújo Gonçalves, P., Leipsic, J. A., ... Chang, H. J. (2022). Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels. JACC: Asia, 2(3, Part 2), 311-319. https://doi.org/10.1016/j.jacasi.2021.10.010

@article{f8169df5702c44d4b08b9d5fae9a101c,

title = "Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels",

abstract = "Background: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9\% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels.",

keywords = "atherosclerosis, coronary computed tomography angiography, hemoglobin",

author = "Won, \{Ki Bum\} and Lee, \{Byoung Kwon\} and Ran Heo and Park, \{Hyung Bok\} and Lin, \{Fay Y.\} and Martin Hadamitzky and Kim, \{Yong Jin\} and Sung, \{Ji Min\} and Edoardo Conte and Daniele Andreini and Gianluca Pontone and Budoff, \{Matthew J.\} and Ilan Gottlieb and Chun, \{Eun Ju\} and Filippo Cademartiri and Erica Maffei and Hugo Marques and \{de Ara{\'u}jo Gon{\c c}alves\}, Pedro and Leipsic, \{Jonathon A.\} and Lee, \{Sang Eun\} and Sanghoon Shin and Choi, \{Jung Hyun\} and Renu Virmani and Habib Samady and Kavitha Chinnaiyan and Berman, \{Daniel S.\} and Jagat Narula and Bax, \{Jeroen J.\} and Min, \{James K.\} and Chang, \{Hyuk Jae\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jun,

doi = "10.1016/j.jacasi.2021.10.010",

language = "English",

volume = "2",

pages = "311--319",

journal = "JACC: Asia",

issn = "2772-3747",

publisher = "Elsevier Inc.",

number = "3, Part 2",

}

Won, KB, Lee, BK, Heo, R, Park, HB, Lin, FY, Hadamitzky, M, Kim, YJ, Sung, JM, Conte, E, Andreini, D, Pontone, G, Budoff, MJ, Gottlieb, I, Chun, EJ, Cademartiri, F, Maffei, E, Marques, H, de Araújo Gonçalves, P, Leipsic, JA, Lee, SE, Shin, S, Choi, JH, Virmani, R, Samady, H, Chinnaiyan, K, Berman, DS, Narula, J, Bax, JJ, Min, JK & Chang, HJ 2022, 'Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels', JACC: Asia, vol. 2, no. 3, Part 2, pp. 311-319. https://doi.org/10.1016/j.jacasi.2021.10.010

TY - JOUR

T1 - Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels

AU - Won, Ki Bum

AU - Lee, Byoung Kwon

AU - Heo, Ran

AU - Park, Hyung Bok

AU - Lin, Fay Y.

AU - Hadamitzky, Martin

AU - Kim, Yong Jin

AU - Sung, Ji Min

AU - Conte, Edoardo

AU - Andreini, Daniele

AU - Pontone, Gianluca

AU - Budoff, Matthew J.

AU - Gottlieb, Ilan

AU - Chun, Eun Ju

AU - Cademartiri, Filippo

AU - Maffei, Erica

AU - Marques, Hugo

AU - de Araújo Gonçalves, Pedro

AU - Leipsic, Jonathon A.

AU - Lee, Sang Eun

AU - Shin, Sanghoon

AU - Choi, Jung Hyun

AU - Virmani, Renu

AU - Samady, Habib

AU - Chinnaiyan, Kavitha

AU - Berman, Daniel S.

AU - Narula, Jagat

AU - Bax, Jeroen J.

AU - Min, James K.

AU - Chang, Hyuk Jae

PY - 2022/6

Y1 - 2022/6

N2 - Background: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels.

AB - Background: Despite a potential role of hemoglobin in atherosclerosis, data on coronary plaque volume changes (PVC) related to serum hemoglobin levels are limited. Objectives: The authors sought to evaluate coronary atherosclerotic plaque burden changes related to serum hemoglobin levels using serial coronary computed tomographic angiography (CCTA). Methods: A total of 830 subjects (age 61 ± 10 years, 51.9% male) who underwent serial CCTA were analyzed. The median interscan period was 3.2 (IQR: 2.5-4.4) years. Quantitative assessment of coronary plaques was performed at both scans. All participants were stratified into 4 groups based on the quartile of baseline hemoglobin levels. Annualized total PVC (mm3/year) was defined as total PVC divided by the interscan period. Results: Baseline total plaque volume (mm3) was not different among all groups (group I [lowest]: 34.1 [IQR: 0.0-127.4] vs group II: 28.8 [IQR: 0.0-123.0] vs group III: 49.9 [IQR: 5.6-135.0] vs group IV [highest]: 34.3 [IQR: 0.0-130.7]; P = 0.235). During follow-up, serum hemoglobin level changes (Δ hemoglobin; per 1 g/dL) was related to annualized total PVC (β = −0.114) in overall participants (P < 0.05). After adjusting for age, sex, traditional risk factors, baseline hemoglobin and creatinine levels, baseline total plaque volume, and the use of aspirin, beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, and statin, Δ hemoglobin significantly affected annualized total PVC in only the composite of groups I and II (β = −2.401; P = 0.004). Conclusions: Serial CCTA findings suggest that Δ hemoglobin has an independent effect on coronary atherosclerosis. This effect might be influenced by baseline hemoglobin levels.

KW - atherosclerosis

KW - coronary computed tomography angiography

KW - hemoglobin

UR - https://www.scopus.com/pages/publications/85132151640

U2 - 10.1016/j.jacasi.2021.10.010

DO - 10.1016/j.jacasi.2021.10.010

M3 - Article

AN - SCOPUS:85132151640

SN - 2772-3747

VL - 2

SP - 311

EP - 319

JO - JACC: Asia

JF - JACC: Asia

IS - 3, Part 2

ER -

Longitudinal Quantitative Assessment of Coronary Atherosclerotic Plaque Burden Related to Serum Hemoglobin Levels

Abstract

Keywords

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