@article{3c3f63143f564757a416662bc7ea2671,
title = "Longitudinal Changes in Neuropsychiatric Symptoms: Impact of Discrepancy in Everyday Preferences Between Persons With Cognitive Impairment and Their Care Partners",
abstract = "Objectives: Neuropsychiatric symptoms (NPS) of dementia are common and may be driven by inability of persons with cognitive impairment (CI) to communicate needs. We addressed the relevance of this unmet-needs model to burden of NPS among persons with milder CI. Methods: The sample included 48 dyads of persons with CI and their care partners. NPS were measured at baseline and follow-up (mean 486 days +/-107 SD). Mixed random and fixed effects longitudinal models were used to evaluate impact of discrepancies between persons with CI and their care partners in everyday preferences (baseline) on changes in NPS over time. Results: Higher levels of underestimation of “social engagement” preferences of persons with CI by care partners were associated with a higher average burden of NPS across all follow-up. Conclusions: This study suggests that unmet-needs may be a useful construct for understanding etiology for NPS across the spectrum of severity of cognitive impairment.",
keywords = "Unmet needs, neuropsychiatric symptoms, surrogate decision-making",
author = "Wilkins, {James M.} and Locascio, {Joseph J.} and Teresa Gomez-Isla and Hyman, {Bradley T.} and Deborah Blacker and Forester, {Brent P.} and Okereke, {Olivia I.}",
note = "Funding Information: Grateful acknowledgement is made of the contributions of Emily Merrill in data collection and processing as well as the MADRC participants and study staff. This study was supported by the Dupont Warren Fellowship, Harvard Medical School, Department of Psychiatry (JMW); Livingston Award, Harvard Medical School, Department of Psychiatry (JMW); Alzheimer's Association Clinician Scientist Fellowship (JMW); National Institutes of Health Loan Repayment Award, L30 AG060475 (JMW); grant P30 AG062421 from the National Institutes of Health (BTH). This work was previously presented as a poster at the Alzheimer's Association International Conference 2021. Funding Information: This work was conducted with support from Harvard Catalyst | The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health Award UL 1TR002541) and financial contributions from Harvard University and its affiliated academic healthcare centers. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic healthcare centers, or the National Institutes of Health. No Disclosures to Report. Publisher Copyright: {\textcopyright} 2021 American Association for Geriatric Psychiatry",
year = "2022",
month = may,
doi = "10.1016/j.jagp.2021.10.007",
language = "English",
volume = "30",
pages = "619--623",
journal = "American Journal of Geriatric Psychiatry",
issn = "1064-7481",
publisher = "Elsevier Inc.",
number = "5",
}