TY - JOUR
T1 - Longitudinal assessment of maternal depression and early childhood asthma and wheeze
T2 - Effect modification by child sex
AU - Alcala, Cecilia S.
AU - Orozco Scott, Paloma
AU - Tamayo-Ortiz, Marcela
AU - Hernández Chávez, Maria del Carmen
AU - Schnaas, Lourdes
AU - Carroll, Kecia N.
AU - Niedzwiecki, Megan M.
AU - Wright, Robert O.
AU - Téllez-Rojo, Martha Maria
AU - Wright, Rosalind J.
AU - Hsu, Hsiao Hsien Leon
AU - Rosa, Maria José
N1 - Funding Information:
This work was supported by NIEHS grants R00ES027496 (Maria José Rosa, PI). Cecilia Sara Alcala was supported by NICHD grant T32HD049311. The PROGRESS project has been supported by grants R01ES014930, R01ES013744, R24ES028522, P30ES023515 (Robert O. Wright, PI), R01ES021357 and R01ES020268 (A. Baccarelli and Robert O. Wright, MPI). The National Institute of Public Health/Ministry of Health of Mexico and the National Institute of Perinatology supported this study. We thank the ABC (American British Cowdray Medical Center) in Mexico for providing some of the needed research facilities. This study was funded by National Institute of Environmental Health Sciences ( doi:10.13039/100000066 ) and Eunice Kennedy Shriver National Institute of Child Health and Human Development ( doi:10.13039/100009633 ).
Funding Information:
This work was supported by NIEHS grants R00ES027496 (Maria José Rosa, PI). Cecilia Sara Alcala was supported by NICHD grant T32HD049311. The PROGRESS project has been supported by grants R01ES014930, R01ES013744, R24ES028522, P30ES023515 (Robert O. Wright, PI), R01ES021357 and R01ES020268 (A. Baccarelli and Robert O. Wright, MPI). The National Institute of Public Health/Ministry of Health of Mexico and the National Institute of Perinatology supported this study. We thank the ABC (American British Cowdray Medical Center) in Mexico for providing some of the needed research facilities. This study was funded by National Institute of Environmental Health Sciences (doi:10.13039/100000066) and Eunice Kennedy Shriver National Institute of Child Health and Human Development (doi:10.13039/100009633).
Publisher Copyright:
© 2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.
PY - 2023/1
Y1 - 2023/1
N2 - Background: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma and wheeze, and explore sex differences. Methods: Maternal depression (n = 601) was assessed using the Edinburgh Depression Scale questionnaire, dichotomized at a clinically relevant cutoff (>12) (a) during pregnancy, (b) postpartum, and (c) postpartum and subsequent time points postnatally (recurrent depression). Report of wheeze in the past 12 months (current wheeze) and asthma were obtained using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire at 48 and 72 months. Associations were analyzed using a modified Poisson regression adjusted for covariates, and in interaction models. Results: Both postpartum and recurrent depression were associated with higher risk of current wheeze (relative risk [RR]: 1.87, 95% confidence interval [CI]: 1.21, 2.90; RR: 2.41, 95% CI: 1.53, 3.79) and asthma at 48 months (RR: 2.42, 95% CI: 1.01, 5.84; RR: 2.45, 95% CI: 1.02, 5.84). In interaction analyses, associations were stronger in females. Recurrent depression was associated with a higher risk of current wheeze at 48 months in females (RR: 4.34, 95% CI: 2.02, 9.32) when compared to males (RR: 1.89, 95% CI: 1.05, 3.39). Conclusions: Postpartum and recurrent depression were associated with a higher risk of wheeze and asthma in children. Understanding the temporal- and sex-specific effects of maternal depression may better inform prevention strategies.
AB - Background: Studies report associations between maternal mental health and adverse respiratory outcomes in children; however, the impact of timing and duration of maternal distress remains understudied. We sought to longitudinally examine associations between maternal depression and childhood asthma and wheeze, and explore sex differences. Methods: Maternal depression (n = 601) was assessed using the Edinburgh Depression Scale questionnaire, dichotomized at a clinically relevant cutoff (>12) (a) during pregnancy, (b) postpartum, and (c) postpartum and subsequent time points postnatally (recurrent depression). Report of wheeze in the past 12 months (current wheeze) and asthma were obtained using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire at 48 and 72 months. Associations were analyzed using a modified Poisson regression adjusted for covariates, and in interaction models. Results: Both postpartum and recurrent depression were associated with higher risk of current wheeze (relative risk [RR]: 1.87, 95% confidence interval [CI]: 1.21, 2.90; RR: 2.41, 95% CI: 1.53, 3.79) and asthma at 48 months (RR: 2.42, 95% CI: 1.01, 5.84; RR: 2.45, 95% CI: 1.02, 5.84). In interaction analyses, associations were stronger in females. Recurrent depression was associated with a higher risk of current wheeze at 48 months in females (RR: 4.34, 95% CI: 2.02, 9.32) when compared to males (RR: 1.89, 95% CI: 1.05, 3.39). Conclusions: Postpartum and recurrent depression were associated with a higher risk of wheeze and asthma in children. Understanding the temporal- and sex-specific effects of maternal depression may better inform prevention strategies.
KW - asthma
KW - childhood wheeze
KW - maternal depression
KW - postpartum depression
KW - respiratory health
UR - http://www.scopus.com/inward/record.url?scp=85139127142&partnerID=8YFLogxK
U2 - 10.1002/ppul.26164
DO - 10.1002/ppul.26164
M3 - Article
C2 - 36128727
AN - SCOPUS:85139127142
VL - 58
SP - 98
EP - 106
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
SN - 8755-6863
IS - 1
ER -