Longitudinal analysis of atherosclerotic cardiovascular disease risk and healthcare costs in newly diagnosed type 2 diabetes in a real-world setting

W. Weng, Y. Liang, J. Brett, T. Hobbs, F. M.M. Baeres

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1 Scopus citations

Abstract

Aims: To assess longitudinal risk for atherosclerotic cardiovascular disease (ASCVD) and cost of healthcare resource utilization over 9 years in patients with or without newly diagnosed type 2 diabetes (T2DM) who had no ASCVD at baseline. Methods: This retrospective, longitudinal analysis of a large, nationwide US administrative claims database compared adults with newly diagnosed T2DM (n = 22,468) and a propensity score matched non-T2DM cohort (n = 22,468). Longitudinal risk of ASCVD and total annual healthcare costs were determined. Subgroup analysis was conducted for 3 age categories: 18–44, 45–64, and 65+ years. Results: From 2006 to 2015, ASCVD was identified in a significantly greater percentage of patients in the T2DM versus non-T2DM cohort (43.2% vs 32.3%; Hazard ratio [HR] = 1.45, P < 0.001). Total annual healthcare cost was markedly higher in T2DM versus non-T2DM cohorts (48.4% higher at year 9). The differences between cohorts were most pronounced in patients aged 18–44 years. Conclusions: This 9-year claims-based retrospective, longitudinal analysis showed a higher risk of ASCVD and higher healthcare costs in newly diagnosed T2DM patients versus those without T2DM, with highest relative risk and cost differences observed in younger patients.

Original languageEnglish
Article number107500
JournalJournal of Diabetes and its Complications
Volume34
Issue number5
DOIs
StatePublished - May 2020
Externally publishedYes

Keywords

  • Atherosclerotic cardiovascular disease
  • Claims
  • Cost
  • Longitudinal
  • Risk
  • Type 2 diabetes mellitus

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