Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant

Jenna D. Goldberg, Joanne F. Chou, Steven Horwitz, Julie Teruya-Feldstein, Juliet N. Barker, Farid Boulad, Hugo Castro-Malaspina, Sergio Giralt, Ann A. Jakubowski, Guenther Koehne, Marcel R.M. Van Den Brink, James W. Young, Zhigang Zhang, Esperanza B. Papadopoulos, Miguel Angel Perales

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Peripheral T-cell non-Hodgkin lymphomas (T-NHL) are rare diseases, with a worse prognosis compared to their B-cell counterparts. Allogeneic hematopoietic stem cell transplant may have a role in the treatment of relapsed/refractory disease or high-risk histologies in the upfront setting. However, there is limited information on the efficacy of allogeneic transplant for these diseases, as well as what factors may predict outcomes. We therefore performed a retrospective study of 34 patients who received an allogeneic transplant for the treatment of T-NHL at a single center between 1 January 1992 and 31 December 2009. The median follow-up for survivors was 45 months (range 9160 months). The 2-year overall survival (OS) was 0.61 (95% confidence interval [CI]: 0.430.75) with a plateau at 28 months. Ki-67 expression ≤ 25% was predictive of improved OS (p < 0.01), and transplant in complete remission was predictive of a decreased cumulative incidence of events (p 0.04). Three patients received a donor leukocyte infusion, and two patients demonstrated a response, supporting a graft-versus-lymphoma effect. These data demonstrate that allogeneic transplant is a viable option for the treatment of T-NHL and merits prospective evaluation.

Original languageEnglish
Pages (from-to)1124-1129
Number of pages6
JournalLeukemia and Lymphoma
Volume53
Issue number6
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • Allogeneic HSCT
  • Graft-versus-lymphoma effect
  • T-cell non-Hodgkin lymphoma

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