Long-term Results of Iodine 125 Irradiation of Uveal Melanoma

Samuel Packer, Scott Stoller, Martin L. Lesser, Francine S. Mandel, Paul T. Finger

Research output: Contribution to journalArticlepeer-review

146 Scopus citations


The authors report on 64 of the first 65 patients treated with iodine 125. The mean follow-up was 64.9 months. After treatment, 29 patients (45.3%) retained visual acuity of 20/100 or better, and 18 patients (28.1%) retained visual acuity within two lines of visual acuity before irradiation. Eleven patients (17.2%) died of metastasis, and 5 patients (7.8%) had local recurrence. Cataract developed in 29 (45.3%) patients; keratitis developed in only 2 (3.1 %) patients, and dry eye developed in none. Neovascular glaucoma developed in 7 (10.9%) patients, and 15 (23.4%) patients had radiation retinopathy. Eleven patients (17.2%) required enucleation for either tumor growth or neovascular glaucoma. These results show the increasing number of radiation complications seen with long-term observation and the frequently seen adverse visual outcome.

Original languageEnglish
Pages (from-to)767-774
Number of pages8
Issue number5
StatePublished - 1992
Externally publishedYes


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