TY - JOUR
T1 - Long-term outcomes and patterns of failure in orbital lymphoma treated with primary radiotherapy
AU - Parikh, Rahul R.
AU - Moskowitz, Bruce K.
AU - Maher, Elizabeth
AU - Della Rocca, David
AU - Della Rocca, Robert
AU - Culliney, Bruce
AU - Shapira, Ilan
AU - Grossbard, Michael L.
AU - Harrison, Louis B.
AU - Hu, Kenneth
N1 - Publisher Copyright:
© 2015 Informa UK, Ltd.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - The purpose of this study was to evaluate the long-term outcome and patterns of failure in patients treated with primary radiotherapy (RT) for orbital lymphoma (OL). Seventy-nine patients diagnosed with stage IE OL between 1995 and 2012 were included. Fifty-nine patients (75%) had mucosa-associated lymphoid tissue lymphoma and 20 patients (25%) had follicular lymphoma subtype. The median follow-up was 49.7 months. Major tumor sites were conjunctiva (29%), orbit (47%) and lacrimal gland (24%). After treatment to a median dose of 30.6 Gy, there were a total of no local, one contralateral orbital, two regional and two distant recurrences, all outside of the treatment fields. The 10-year local relapse-free, distant metastasis-free and overall survival rates were 100%, 94.2% and 98.2%, respectively. Definitive RT to 30 Gy was shown to be highly effective for indolent OL, and this study represents one of the largest single-institution studies using primary RT for stage IE OL.
AB - The purpose of this study was to evaluate the long-term outcome and patterns of failure in patients treated with primary radiotherapy (RT) for orbital lymphoma (OL). Seventy-nine patients diagnosed with stage IE OL between 1995 and 2012 were included. Fifty-nine patients (75%) had mucosa-associated lymphoid tissue lymphoma and 20 patients (25%) had follicular lymphoma subtype. The median follow-up was 49.7 months. Major tumor sites were conjunctiva (29%), orbit (47%) and lacrimal gland (24%). After treatment to a median dose of 30.6 Gy, there were a total of no local, one contralateral orbital, two regional and two distant recurrences, all outside of the treatment fields. The 10-year local relapse-free, distant metastasis-free and overall survival rates were 100%, 94.2% and 98.2%, respectively. Definitive RT to 30 Gy was shown to be highly effective for indolent OL, and this study represents one of the largest single-institution studies using primary RT for stage IE OL.
KW - Chemotherapeutic approaches
KW - Lymphoma and Hodgkin disease
KW - Radiation
UR - http://www.scopus.com/inward/record.url?scp=84932099526&partnerID=8YFLogxK
U2 - 10.3109/10428194.2014.979415
DO - 10.3109/10428194.2014.979415
M3 - Article
C2 - 25356924
AN - SCOPUS:84932099526
VL - 56
SP - 1266
EP - 1270
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 5
ER -