Long-term outcomes and patterns of failure in orbital lymphoma treated with primary radiotherapy

Rahul R. Parikh, Bruce K. Moskowitz, Elizabeth Maher, David Della Rocca, Robert Della Rocca, Bruce Culliney, Ilan Shapira, Michael L. Grossbard, Louis B. Harrison, Kenneth Hu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The purpose of this study was to evaluate the long-term outcome and patterns of failure in patients treated with primary radiotherapy (RT) for orbital lymphoma (OL). Seventy-nine patients diagnosed with stage IE OL between 1995 and 2012 were included. Fifty-nine patients (75%) had mucosa-associated lymphoid tissue lymphoma and 20 patients (25%) had follicular lymphoma subtype. The median follow-up was 49.7 months. Major tumor sites were conjunctiva (29%), orbit (47%) and lacrimal gland (24%). After treatment to a median dose of 30.6 Gy, there were a total of no local, one contralateral orbital, two regional and two distant recurrences, all outside of the treatment fields. The 10-year local relapse-free, distant metastasis-free and overall survival rates were 100%, 94.2% and 98.2%, respectively. Definitive RT to 30 Gy was shown to be highly effective for indolent OL, and this study represents one of the largest single-institution studies using primary RT for stage IE OL.

Original languageEnglish
Pages (from-to)1266-1270
Number of pages5
JournalLeukemia and Lymphoma
Volume56
Issue number5
DOIs
StatePublished - 1 May 2015
Externally publishedYes

Keywords

  • Chemotherapeutic approaches
  • Lymphoma and Hodgkin disease
  • Radiation

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