Long-term outcomes after heart transplantation using ex vivo allograft perfusion in standard risk donors: A single-center experience

Qiudong Chen, Tahli Singer-Englar, Jon A. Kobashigawa, Amy Roach, Dominic Emerson, Dominick Megna, Danny Ramzy, Pedro Catarino, Jignesh K. Patel, Michelle Kittleson, Lawrence Czer, Joanna Chikwe, Fardad Esmailian

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Introduction: The Organ Care System (OCS) is an ex vivo perfusion platform for donor heart preservation. Short/mid-term post-transplant outcomes after its use are comparable to standard cold storage (CS). We evaluated long-term outcomes following its use. Methods: Between 2011 and 2013, 38 patients from a single center were randomized as a part of the PROCEED II trial to receive allografts preserved with CS (n = 19) or OCS (n = 19). Endpoints included 8-year survival, survival free from graft-related deaths, freedom from cardiac allograft vasculopathy (CAV), non-fatal major adverse cardiac events (NF-MACE), and rejections. Results: Eight-year survival was 57.9% in the OCS group and 73.7% in the CS group (p =.24). Freedom from CAV was 89.5% in the OCS group and 67.8% in the CS group (p =.13). Freedom from NF-MACE was 89.5% in the OCS group and 67.5% in the CS group (p =.14). Eight-year survival free from graft-related death was equivalent between the two groups (84.2% vs. 84.2%, p =.93). No differences in rejection episodes were observed (all p >.5). Conclusions: In select patients receiving OCS preserved allografts, late post-transplant survival trended lower than those transplanted with an allograft preserved with CS. This is based on a small single-center series, and larger numbers are needed to confirm these findings.

Original languageEnglish
Article numbere14591
JournalClinical Transplantation
Volume36
Issue number5
DOIs
StatePublished - May 2022
Externally publishedYes

Keywords

  • heart (allograft) function/dysfunction
  • heart disease
  • organ perfusion and preservation
  • patient survival

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