Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates

Julia Karbach; Sacha Gnjatic; Melina Biskamp; Akin Atmaca; Eckhart Weidmann; Kathrin Brandt; Claudia Wahle; Helga Bernhard; Alexander Knuth; Elke Jäger

doi:10.1158/2326-6066.CIR-13-0200

Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates

Julia Karbach
, Sacha Gnjatic
, Melina Biskamp
, Akin Atmaca
, Eckhart Weidmann
, Kathrin Brandt
, Claudia Wahle
, Helga Bernhard
, Alexander Knuth
, Elke Jäger

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated "auto-vaccination," the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.

Original language	English
Pages (from-to)	404-409
Number of pages	6
Journal	Cancer immunology research
Volume	2
Issue number	5
DOIs	https://doi.org/10.1158/2326-6066.CIR-13-0200
State	Published - 1 May 2014
Externally published	Yes

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10.1158/2326-6066.CIR-13-0200

Cite this

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title = "Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates",

abstract = "A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated {"}auto-vaccination,{"} the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.",

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T1 - Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis

T2 - immunologic correlates

AU - Karbach, Julia

AU - Gnjatic, Sacha

AU - Biskamp, Melina

AU - Atmaca, Akin

AU - Weidmann, Eckhart

AU - Brandt, Kathrin

AU - Wahle, Claudia

AU - Bernhard, Helga

AU - Knuth, Alexander

AU - Jäger, Elke

PY - 2014/5/1

Y1 - 2014/5/1

N2 - A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated "auto-vaccination," the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.

AB - A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated "auto-vaccination," the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.

UR - https://www.scopus.com/pages/publications/84922394929

U2 - 10.1158/2326-6066.CIR-13-0200

DO - 10.1158/2326-6066.CIR-13-0200

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JF - Cancer immunology research

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ER -

Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis: immunologic correlates

Abstract

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