TY - JOUR
T1 - Long-term complete remission following radiosurgery and immunotherapy in a melanoma patient with brain metastasis
T2 - immunologic correlates
AU - Karbach, Julia
AU - Gnjatic, Sacha
AU - Biskamp, Melina
AU - Atmaca, Akin
AU - Weidmann, Eckhart
AU - Brandt, Kathrin
AU - Wahle, Claudia
AU - Bernhard, Helga
AU - Knuth, Alexander
AU - Jäger, Elke
PY - 2014/5/1
Y1 - 2014/5/1
N2 - A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated "auto-vaccination," the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.
AB - A melanoma patient with brain metastases was treated by gamma-knife radiosurgery and immunotherapy with autologous tumor-lysate-loaded dendritic cells (DC). Ten years after the combined treatment, the patient remains in complete remission. Remarkable immunologic correlates to the clinical development were the transient induction of NY-ESO-1 antibody and the durable expansion of MAGE-A1p161-169 EADPTGHSY-specific CD8+ T cells. Although the induction of NY-ESO-1 antibody most likely resulted from gamma-knife-mediated "auto-vaccination," the persistence of circulating MAGE-A1-specific T cells, which are still detectable ex vivo in the absence of any tumor manifestation, coincides with DC-based vaccination administered monthly until today.
UR - https://www.scopus.com/pages/publications/84922394929
U2 - 10.1158/2326-6066.CIR-13-0200
DO - 10.1158/2326-6066.CIR-13-0200
M3 - Article
C2 - 24795353
AN - SCOPUS:84922394929
SN - 2326-6066
VL - 2
SP - 404
EP - 409
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 5
ER -