TY - JOUR
T1 - Long-segment nerve allograft regeneration in the sheep model
T2 - Experimental study and review of the literature
AU - Strasberg, Suzanne R.
AU - Mackinnon, Susan E.
AU - Genden, Eric M.
AU - Bain, James R.
AU - Purcell, Carrie M.
AU - Hunter, Daniel A.
AU - Hay, John B.
PY - 1996/11
Y1 - 1996/11
N2 - Experimental work in the field of nerve allotransplantation has dealt with the feasibility of nerve allografts reconstructing nerve gaps. In the majority of studies, the nerve gap studied has been short, and some degree of regeneration has been achieved, even inn the untreated allograft. To better approximate clinical nerve-allograft reconstruction, a series of long- segment (8-cm) nerve allografts were performed in the ovine model. Twenty outbred ewes were randomized into two experimental groups with four experimental conditions. Animals received nerve allografts treated under one of the following conditions: fresh nerve autograft, fresh nerve allograft, cold-preserved nerve autograft, or cold-preserved nerve allograft. The nerve grafts were examined and compared at 6 and 10 months, using histological, morphometric, and electrophysiologic analyses. The results of the study demonstrated that, while excellent regeneration occurred across the nerve autograft, the long nerve allograft could not support axonal elongation. Similarly, cold nerve gap and may be beneficial in a better correlation of experimental nerve transplantation with clinical conditions.
AB - Experimental work in the field of nerve allotransplantation has dealt with the feasibility of nerve allografts reconstructing nerve gaps. In the majority of studies, the nerve gap studied has been short, and some degree of regeneration has been achieved, even inn the untreated allograft. To better approximate clinical nerve-allograft reconstruction, a series of long- segment (8-cm) nerve allografts were performed in the ovine model. Twenty outbred ewes were randomized into two experimental groups with four experimental conditions. Animals received nerve allografts treated under one of the following conditions: fresh nerve autograft, fresh nerve allograft, cold-preserved nerve autograft, or cold-preserved nerve allograft. The nerve grafts were examined and compared at 6 and 10 months, using histological, morphometric, and electrophysiologic analyses. The results of the study demonstrated that, while excellent regeneration occurred across the nerve autograft, the long nerve allograft could not support axonal elongation. Similarly, cold nerve gap and may be beneficial in a better correlation of experimental nerve transplantation with clinical conditions.
UR - http://www.scopus.com/inward/record.url?scp=0029826755&partnerID=8YFLogxK
U2 - 10.1055/s-2007-1006625
DO - 10.1055/s-2007-1006625
M3 - Article
C2 - 8951121
AN - SCOPUS:0029826755
SN - 0743-684X
VL - 12
SP - 529
EP - 537
JO - Journal of Reconstructive Microsurgery
JF - Journal of Reconstructive Microsurgery
IS - 8
ER -