Long-range cortical GABA neurons oppose binge drinking

Jun Shi Wang; Paul J. Kenny

doi:10.1038/s41593-025-02030-0

Long-range cortical GABA neurons oppose binge drinking

Jun Shi Wang
, Paul J. Kenny

Research output: Contribution to journal › Article › peer-review

Abstract

Binge drinking is widespread, but its underlying cellular mechanisms remain unclear. A recent study identifies a sparse ensemble of GABAergic neurons in the medial orbitofrontal cortex that is activated during binge drinking. These neurons send inhibitory projections to subcortical regions to limit alcohol intake, suggesting new strategies to reduce binge drinking and protect against alcohol use disorder.

Original language	English
Pages (from-to)	1578-1579
Number of pages	2
Journal	Nature Neuroscience
Volume	28
Issue number	8
DOIs	https://doi.org/10.1038/s41593-025-02030-0
State	Published - Aug 2025

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title = "Long-range cortical GABA neurons oppose binge drinking",

abstract = "Binge drinking is widespread, but its underlying cellular mechanisms remain unclear. A recent study identifies a sparse ensemble of GABAergic neurons in the medial orbitofrontal cortex that is activated during binge drinking. These neurons send inhibitory projections to subcortical regions to limit alcohol intake, suggesting new strategies to reduce binge drinking and protect against alcohol use disorder.",

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AB - Binge drinking is widespread, but its underlying cellular mechanisms remain unclear. A recent study identifies a sparse ensemble of GABAergic neurons in the medial orbitofrontal cortex that is activated during binge drinking. These neurons send inhibitory projections to subcortical regions to limit alcohol intake, suggesting new strategies to reduce binge drinking and protect against alcohol use disorder.

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JO - Nature Neuroscience

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Long-range cortical GABA neurons oppose binge drinking

Abstract

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